Histone deacetylase 3 (Q21154358)

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mammalian protein found in Homo sapiens
  • SMAP45
  • RPD3-2
  • histone deacetylase 3
  • HDAC3
edit
Language Label Description Also known as
English
Histone deacetylase 3
mammalian protein found in Homo sapiens
  • SMAP45
  • RPD3-2
  • histone deacetylase 3
  • HDAC3

Statements

molecular function
histone deacetylase activity
determination method
TAS
IMP
IEA
6 references
retrieved
27 March 2018
stated in
Class II histone deacetylases: versatile regulators
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379
determination method
TAS
retrieved
27 March 2018
stated in
Histone deacetylases specifically down-regulate p53-dependent gene activation
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379
determination method
TAS
retrieved
27 March 2018
stated in
A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379
determination method
IMP
retrieved
27 March 2018
stated in
Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379
determination method
IMP
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379
determination method
IEA
protein binding
determination method
IPI
38 references
retrieved
8 April 2019
stated in
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
NKAP is a transcriptional repressor of notch signaling and is required for T cell development
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
A BEN-domain-containing protein associates with heterochromatin and represses transcription
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
HDAC3 is negatively regulated by the nuclear protein DBC1
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
BCoR, a novel corepressor involved in BCL-6 repression
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
The methyl-CpG binding protein MBD1 is required for PML-RARalpha function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Global landscape of HIV-human protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
retrieved
8 April 2019
stated in
The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IPI
histone deacetylase activity
determination method
IBA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
Class II histone deacetylases: versatile regulators
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
TAS
retrieved
8 April 2019
stated in
Histone deacetylases specifically down-regulate p53-dependent gene activation
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
TAS
retrieved
8 April 2019
stated in
Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IMP
retrieved
8 April 2019
stated in
A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IBA
cell component
nucleus
determination method
IDA
TAS
IEA
6 references
retrieved
8 April 2019
stated in
Class II histone deacetylases: versatile regulators
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
TAS
retrieved
8 April 2019
stated in
Characterization of a human RPD3 ortholog, HDAC3
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IEA
retrieved
8 April 2019
stated in
HDAC3 is negatively regulated by the nuclear protein DBC1
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IDA
retrieved
8 April 2019
stated in
Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment
GOA
curator
UniProt
UniProt protein ID
O15379
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IDA
retrieved
8 April 2019
stated in
Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379
determination method
IDA
biological process
physically interacts with

Identifiers

 
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