Cathepsin Z (Q21154413)

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mammalian protein found in Homo sapiens

lysosomal carboxypeptidase B
cathepsin X
CTSZ
cathepsin P
cathepsin B2
cysteine-type carboxypeptidase
carboxypeptidase LB
cathepsin IV
preprocathepsin P
cathepsin Y
cathepsin Z
cathepsin Z1

Language	Label	Description	Also known as
English	Cathepsin Z	mammalian protein found in Homo sapiens	lysosomal carboxypeptidase B cathepsin X CTSZ cathepsin P cathepsin B2 cysteine-type carboxypeptidase carboxypeptidase LB cathepsin IV preprocathepsin P cathepsin Y cathepsin Z cathepsin Z1

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBR2

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBR2

1 reference

based on heuristic

inferred from protein domain or family

Cysteine peptidase, asparagine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

cysteine-type endopeptidase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

cysteine-type peptidase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

carboxypeptidase activity

determination method

1 reference

8 April 2019

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

endoplasmic reticulum lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

COPII-coated ER to Golgi transport vesicle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

plasma membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

endoplasmic reticulum-Golgi intermediate compartment membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

extracellular exosome

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

extracellular region

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

specific granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

ficolin-1-rich granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

extracellular space

determination method

3 references

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBR2&geneProductId=UniProtKB:Q9UBR2

determination method

26 September 2017

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBR2&geneProductId=UniProtKB:Q9UBR2

determination method

26 September 2017

Proteomics characterization of extracellular space components in the human aorta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBR2&geneProductId=UniProtKB:Q9UBR2

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

extracellular space

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

biological process

proteolysis involved in cellular protein catabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

COPII vesicle coating

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

endoplasmic reticulum to Golgi vesicle-mediated transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

epithelial tube branching involved in lung morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

angiotensin maturation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

determination method

4 references

8 April 2019

Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

negative regulation of plasminogen activation

determination method

1 reference

8 April 2019

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

negative regulation of neuron projection development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

negative regulation of protein binding

determination method

1 reference

8 April 2019

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

positive regulation of neuron apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

regulation of neuron death

determination method

1 reference

8 April 2019

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

positive regulation of neural precursor cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBR2

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Peptidase C1A, papain C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBR2

Cysteine peptidase, asparagine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBR2

Identifiers

MeSH descriptor ID

subject named as

Cathepsin Z

0 references

D08.811.277.656.224.425

0 references

D08.811.277.656.262.249

0 references

D08.811.277.656.350.245.270

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000217131

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000217131

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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