Centromere protein F (Q21154957)

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mammalian protein found in Homo sapiens

mitosin
CENP-F kinetochore protein
cell-cycle-dependent 350K nuclear protein
centromere protein F
CENPF
centromere protein F, 350/400kDa
kinetochore protein CENPF
AH antigen

Language	Label	Description	Also known as
English	Centromere protein F	mammalian protein found in Homo sapiens	mitosin CENP-F kinetochore protein cell-cycle-dependent 350K nuclear protein centromere protein F CENPF centromere protein F, 350/400kDa kinetochore protein CENPF AH antigen

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Centromere protein Cenp-F, leucine-rich repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Centromere protein Cenp-F, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

chromatin binding

determination method

1 reference

8 April 2019

Structural requirements and dynamics of mitosin-kinetochore interaction in M phase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

protein C-terminus binding

determination method

1 reference

8 April 2019

The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

protein binding

determination method

8 references

8 April 2019

Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

ciliary basal body

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

nuclear envelope

determination method

1 reference

8 April 2019

Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

outer kinetochore

determination method

4 references

8 April 2019

Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

Structural requirements and dynamics of mitosin-kinetochore interaction in M phase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

chromosome, centromeric region

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

biological process

regulation of G2/M transition of mitotic cell cycle

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

metaphase plate congression

determination method

1 reference

8 April 2019

Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

DNA biosynthetic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

kidney development

determination method

1 reference

8 April 2019

The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

chromosome segregation

determination method

muscle organ development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

ventricular system development

determination method

1 reference

8 April 2019

The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

mitotic spindle assembly checkpoint signaling

determination method

1 reference

8 April 2019

Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

regulation of cell cycle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Mitosin/CENP-F as a negative regulator of activating transcription factor-4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

kinetochore assembly

determination method

1 reference

8 April 2019

Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

mitotic cell cycle

determination method

1 reference

8 April 2019

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49454

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Centromere protein Cenp-F, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49454

Centromere protein Cenp-F, leucine-rich repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49454

Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49454

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000355922

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355922

ENSP00000478221

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478221

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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