Histidine rich glycoprotein (Q21155914)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

3 references

17 October 2017

17 October 2017

The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

17 October 2017

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

cysteine-type endopeptidase inhibitor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

zinc ion binding

3 references

17 October 2017

Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

17 October 2017

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

17 October 2017

The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

immunoglobulin binding

1 reference

8 April 2019

Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

protein binding

8 references

8 April 2019

Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

heme binding

1 reference

8 April 2019

Human serum histidine-rich glycoprotein. I. Interactions with heme, metal ions and organic ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

serine-type endopeptidase inhibitor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

heparan sulfate proteoglycan binding

signaling receptor binding

1 reference

8 April 2019

The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

heparin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

4 references

8 April 2019

8 April 2019

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

zinc ion binding

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

cell component

endolysosome

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

blood microparticle

1 reference

17 October 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

5 references

17 October 2017

17 October 2017

The human plasma proteome: a nonredundant list developed by combination of four separate sources

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

17 October 2017

17 October 2017

Histidine-rich glycoprotein protects from systemic Candida infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

17 October 2017

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

extracellular exosome

3 references

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

platelet alpha granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

cell surface

1 reference

8 April 2019

Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

6 references

8 April 2019

8 April 2019

The human plasma proteome: a nonredundant list developed by combination of four separate sources

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

8 April 2019

Histidine-rich glycoprotein protects from systemic Candida infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

collagen-containing extracellular matrix

3 references

8 April 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

blood microparticle

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

biological process

hemostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

negative regulation of cell adhesion

1 reference

8 April 2019

A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of fibrinolysis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

regulation of actin cytoskeleton organization

1 reference

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of blood vessel endothelial cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

positive regulation of immune response to tumor cell

ISS

1 reference

8 April 2019

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

platelet degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

heme transport

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of endothelial cell chemotaxis

3 references

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

positive regulation of blood vessel remodeling

1 reference

8 April 2019

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of cell growth

1 reference

8 April 2019

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

positive regulation of apoptotic process

1 reference

8 April 2019

A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

regulation of gene expression

1 reference

8 April 2019

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of angiogenesis

4 references

8 April 2019

Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

8 April 2019

The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

positive regulation of focal adhesion assembly

negative regulation of vascular endothelial growth factor signaling pathway

1 reference

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

regulation of blood coagulation

regulation of protein-containing complex assembly

1 reference

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of cell adhesion mediated by integrin

1 reference

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of cell population proliferation

1 reference

8 April 2019

A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of lamellipodium assembly

1 reference

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

blood coagulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

8 April 2019

platelet activation

1 reference

8 April 2019

Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of endopeptidase activity

1 reference

17 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196

antimicrobial humoral immune response mediated by antimicrobial peptide

1 reference

8 April 2019

Histidine-rich glycoprotein protects from systemic Candida infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

negative regulation of endopeptidase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196

1 reference

InterPro Release 71.0