Signal transducer and activator of transcription 2 (Q21156484)

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mammalian protein found in Homo sapiens

p113
interferon alpha induced transcriptional activator
STAT2
signal transducer and activator of transcription 2, 113kDa
signal transducer and activator of transcription 2
STAT2 Transcription Factor

Language	Label	Description	Also known as
English	Signal transducer and activator of transcription 2	mammalian protein found in Homo sapiens	p113 interferon alpha induced transcriptional activator STAT2 signal transducer and activator of transcription 2, 113kDa signal transducer and activator of transcription 2 STAT2 Transcription Factor

Statements

1 reference

16 January 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

STAT transcription factor, DNA-binding, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

transcription factor STAT

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

STAT transcription factor, coiled coil

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

STAT transcription factor, N-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

STAT transcription factor, protein interaction, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Signal transducer and activation of transcription 2, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

STAT transcription factor, DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

STAT2, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

STAT transcription factor, all-alpha domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

molecular function

DNA-binding transcription factor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

protein binding

determination method

14 references

9 May 2019

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Affinity of Stat2 for the subunits of the interferon alpha receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Acetylation-dependent signal transduction for type I interferon receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Divergent susceptibilities of human herpesvirus 6 variants to type I interferons

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

identical protein binding

determination method

1 reference

9 May 2019

The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

ubiquitin-like protein ligase binding

determination method

1 reference

9 May 2019

Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

signal transducer activity

determination method

1 reference

24 April 2018

Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52630&geneProductId=UniProtKB:P52630

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

plasma membrane

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

determination method

2 references

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

determination method

determination method

biological process

receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52630&geneProductId=UniProtKB:P52630

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

signal transduction

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

regulation of mitochondrial fission

determination method

1 reference

9 May 2019

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

defense response

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

regulation of cell population proliferation

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

response to peptide hormone

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

type I interferon signaling pathway

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

STAT2 deficiency and susceptibility to viral illness in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52630

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

Signal transducer and activation of transcription 2, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

STAT transcription factor, all-alpha domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

STAT transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

STAT transcription factor, protein interaction

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

STAT2, SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P52630

Identifiers

MeSH descriptor ID

subject named as

STAT2 Transcription Factor

0 references

D12.644.360.024.303.500.750

0 references

D12.644.360.024.342.200

0 references

D12.776.157.057.061.500.750

0 references

D12.776.157.057.186.200

0 references

D12.776.260.513.249.750

0 references

D12.776.476.024.386.500.750

0 references

D12.776.476.024.430.200

0 references

D12.776.930.354.249.750

0 references

RefSeq protein ID

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

Ensembl protein ID

ENSP00000315768

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000315768

ENSP00000450751

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000450751

ENSP00000387354

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000387354

ENSP00000450985

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000450985

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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