Mitogen-activated protein kinase kinase kinase 8 (Q21157903)

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mammalian protein found in Homo sapiens
  • tumor progression locus 2
  • augmented in rheumatoid arthritis 2
  • Serine/threonine-protein kinase cot
  • proto-oncogene c-Cot
  • TPL-2
  • MAP3K8
  • proto-oncogene serine/threoine protein kinase
  • Cancer Osaka thyroid oncogene
  • cot (cancer Osaka thyroid) oncogene
  • Ewing sarcoma transformant
  • mitogen-activated protein kinase kinase kinase 8
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Language Label Description Also known as
English
Mitogen-activated protein kinase kinase kinase 8
mammalian protein found in Homo sapiens
  • tumor progression locus 2
  • augmented in rheumatoid arthritis 2
  • Serine/threonine-protein kinase cot
  • proto-oncogene c-Cot
  • TPL-2
  • MAP3K8
  • proto-oncogene serine/threoine protein kinase
  • Cancer Osaka thyroid oncogene
  • cot (cancer Osaka thyroid) oncogene
  • Ewing sarcoma transformant
  • mitogen-activated protein kinase kinase kinase 8

Statements

molecular function
protein binding
determination method
IPI
8 references
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279
determination method
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279
determination method
IPI
retrieved
8 April 2019
stated in
ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279
determination method
IPI
retrieved
8 April 2019
stated in
COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41279
determination method
IPI
biological process

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21157903&oldid=2023033233"