Fibroblast growth factor receptor substrate 2 (Q21172873)

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mammalian protein found in Homo sapiens

epididymis secretory sperm binding protein
FGFR-signaling adaptor SNT
FGFR signalling adaptor
SNT-1
FGFR substrate 2
fibroblast growth factor receptor substrate 2
suc1-associated neurotrophic factor target 1
FRS2

Language	Label	Description	Also known as
English	Fibroblast growth factor receptor substrate 2	mammalian protein found in Homo sapiens	epididymis secretory sperm binding protein FGFR-signaling adaptor SNT FGFR signalling adaptor SNT-1 FGFR substrate 2 fibroblast growth factor receptor substrate 2 suc1-associated neurotrophic factor target 1 FRS2

Statements

1 reference

13 November 2019

UniProt protein ID

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

FRS2, PTB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

IRS-type PTB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

fibroblast growth factor receptor binding

determination method

1 reference

8 April 2019

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

neurotrophin TRKA receptor binding

determination method

1 reference

8 April 2019

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

protein binding

determination method

3 references

8 April 2019

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

8 April 2019

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

phosphatase activator activity

determination method

1 reference

8 April 2019

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

1-phosphatidylinositol-3-kinase activity

determination method

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WU20&geneProductId=UniProtKB:Q8WU20

determination method

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

determination method

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WU20&geneProductId=UniProtKB:Q8WU20

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WU20&geneProductId=UniProtKB:Q8WU20

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

endomembrane system

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

cell-cell junction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

biological process

regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

ventricular septum development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

organ induction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

gastrulation with mouth forming second

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

lens placode formation involved in camera-type eye formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

fibroblast growth factor receptor signaling pathway

determination method

4 references

8 April 2019

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

8 April 2019

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

transmembrane receptor protein tyrosine phosphatase signaling pathway

determination method

1 reference

8 April 2019

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

lens development in camera-type eye

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

regulation of ERK1 and ERK2 cascade

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

neuroblast proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

forebrain development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

regulation of epithelial cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

anterior/posterior axis specification, embryo

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

lens fiber cell development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

phosphatidylinositol phosphate biosynthetic process

determination method

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WU20&geneProductId=UniProtKB:Q8WU20

determination method

phosphatidylinositol-3-phosphate biosynthetic process

determination method

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WU20&geneProductId=UniProtKB:Q8WU20

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

negative regulation of cardiac muscle cell differentiation

determination method

1 reference

8 April 2019

Overexpression of microRNA-1 promotes cardiomyocyte commitment from human cardiovascular progenitors via suppressing WNT and FGF signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

neurotrophin TRK receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WU20

determination method

IRS-type PTB domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8WU20

FRS2, PTB domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8WU20

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000381083

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381083

ENSP00000447241

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447241

ENSP00000450048

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450048

ENSP00000447007

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447007

ENSP00000447724

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447724

ENSP00000447804

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447804

ENSP00000447978

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447978

ENSP00000449105

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449105

ENSP00000449111

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449111

ENSP00000449432

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449432

ENSP00000450000

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450000

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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