Maternal embryonic leucine zipper kinase (Q21173216)

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mammalian protein found in Homo sapiens

maternal embryonic leucine zipper kinase
protein kinase Eg3
hPK38
tyrosine-protein kinase MELK
2.7.10.2
protein kinase PK38
MELK
pEg3 kinase

Language	Label	Description	Also known as
English	Maternal embryonic leucine zipper kinase	mammalian protein found in Homo sapiens	maternal embryonic leucine zipper kinase protein kinase Eg3 hPK38 tyrosine-protein kinase MELK 2.7.10.2 protein kinase PK38 MELK pEg3 kinase

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14680

KA1 domain/Ssp2, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14680

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Maternal embryonic leucine zipper kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Kinase associated domain 1 (KA1), protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

calcium ion binding

determination method

1 reference

8 April 2019

Substrate specificity and activity regulation of protein kinase MELK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

protein serine/threonine kinase activity

determination method

7 references

24 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

24 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

24 October 2017

Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

24 October 2017

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

24 October 2017

Substrate specificity and activity regulation of protein kinase MELK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

24 October 2017

Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

protein binding

determination method

4 references

8 April 2019

Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

determination method

2 references

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

protein serine/threonine kinase activity

determination method

8 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Substrate specificity and activity regulation of protein kinase MELK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

non-membrane spanning protein tyrosine kinase activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Substrate specificity and activity regulation of protein kinase MELK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

determination method

1 reference

24 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

determination method

1 reference

8 April 2019

Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

biological process

intrinsic apoptotic signaling pathway in response to oxidative stress

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

intracellular signal transduction

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

protein phosphorylation

determination method

1 reference

24 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14680&geneProductId=UniProtKB:Q14680

determination method

G2/M transition of mitotic cell cycle

determination method

1 reference

8 April 2019

Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

protein autophosphorylation

determination method

1 reference

8 April 2019

Substrate specificity and activity regulation of protein kinase MELK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14680

determination method

EC enzyme number

2.7.10.2

1 reference

14 November 2015

http://www.uniprot.org/uniprot/Q14680.txt?version=149

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14680

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14680

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14680

Kinase associated domain 1 (KA1)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14680

Maternal embryonic leucine zipper kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14680

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000298048

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000298048

ENSP00000437804

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000437804

ENSP00000439184

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000439184

ENSP00000439792

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000439792

ENSP00000441596

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441596

ENSP00000443550

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443550

ENSP00000445452

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445452

ENSP00000486459

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486459

ENSP00000486558

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486558

ENSP00000486717

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486717

ENSP00000487536

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487536

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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