Kelch like ECH associated protein 1 (Q21173646)

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mammalian protein found in Homo sapiens
  • KEAP1
  • INrf2
  • KEAP1 delta C
  • cytosolic inhibitor of Nrf2
  • kelch-like family member 19
  • kelch-like ECH-associated protein 1
  • kelch-like protein 19
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Language Label Description Also known as
English
Kelch like ECH associated protein 1
mammalian protein found in Homo sapiens
  • KEAP1
  • INrf2
  • KEAP1 delta C
  • cytosolic inhibitor of Nrf2
  • kelch-like family member 19
  • kelch-like ECH-associated protein 1
  • kelch-like protein 19

Statements

molecular function
protein binding
determination method
IPI
24 references
retrieved
8 April 2019
stated in
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites
GOA
curator
UniProt
UniProt protein ID
Q14145
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
GOA
curator
UniProt
UniProt protein ID
Q14145
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
GOA
curator
UniProt
UniProt protein ID
Q14145
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level
GOA
curator
UniProt
UniProt protein ID
Q14145
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
A mechanism for the suppression of homologous recombination in G1 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
retrieved
8 April 2019
stated in
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145
determination method
IPI
cell component
biological process

Identifiers

PDB structure ID
 
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