AXL receptor tyrosine kinase (Q21201523)

Immunoglobulin-like fold

1 reference

Protein kinase-like domain superfamily

1 reference

Immunoglobulin-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Immunoglobulin subtype, protein family

1 reference

Protein kinase domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

protein kinase activity

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

virus receptor activity

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

2 references

phosphatidylserine binding

1 reference

8 April 2019

The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

6 references

8 April 2019

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

Structural basis for Gas6-Axl signalling.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

phosphatidylinositol 3-kinase binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

myosin heavy chain binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

EXP

3 references

8 April 2019

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

cell component

extracellular exosome

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

integral component of plasma membrane

1 reference

26 September 2017

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30530&geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

intracellular anatomical structure

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30530&geneProductId=UniProtKB:P30530

2 references

1 reference

8 April 2019

Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

protein kinase B signaling

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

positive regulation of natural killer cell differentiation

1 reference

8 April 2019

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

apoptotic cell clearance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

negative regulation of lymphocyte activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

negative regulation of apoptotic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30530&geneProductId=UniProtKB:P30530

1 reference

8 April 2019

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

natural killer cell differentiation

TAS

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30530&geneProductId=UniProtKB:P30530

negative regulation of interferon-gamma production

1 reference

8 April 2019

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

cellular response to lipopolysaccharide

1 reference

8 April 2019

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

vascular endothelial growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

substrate adhesion-dependent cell spreading

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

erythrocyte homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

positive regulation of protein kinase B signaling

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30530&geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

positive regulation of cytokine-mediated signaling pathway

1 reference

8 April 2019

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

cellular response to interferon-alpha

1 reference

8 April 2019

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

forebrain cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

viral entry into host cell

1 reference

8 April 2019

The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

negative regulation of dendritic cell apoptotic process

IMP

1 reference

8 April 2019

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

protein phosphorylation

1 reference

8 April 2019

cellular response to extracellular stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

enzyme linked receptor protein signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

positive regulation of pinocytosis

1 reference

8 April 2019

The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

negative regulation of neuron apoptotic process

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

innate immune response

1 reference

8 April 2019

blood vessel remodeling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

dendritic cell differentiation

IEP

1 reference

8 April 2019

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30530&geneProductId=UniProtKB:P30530

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

immune system process

1 reference

8 April 2019

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

cellular response to hydrogen peroxide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

animal organ regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

negative regulation of cytokine production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

nervous system development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30530

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301622

on focus list of Wikimedia project

WikiProject Zika Corpus

0 references

has part(s)

tyrosine-protein kinase, active site

1 reference

fibronectin type III

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

immunoglobulin-like domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

immunoglobulin subtype

1 reference

D08.811.913.696.620.682.725.400.975

Identifiers

MeSH descriptor ID

D000094963

subject named as

Axl Receptor Tyrosine Kinase

0 references

MeSH tree code

0 references

D12.776.476.568.400.975

0 references

D12.776.543.750.630.875

0 references

D12.776.624.664.700.013

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

2 August 2016

language of work or name

1 reference

2 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata