Protein arginine methyltransferase 1 (Q21201642)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99873

Protein arginine N-methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99873

1 reference

13 November 2019

1 reference

13 November 2019

methyltransferase activity

TAS

histone methyltransferase activity

3 references

1 reference

17 October 2017

Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

histone methyltransferase activity (H4-R3 specific)

1 reference

8 April 2019

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

mitogen-activated protein kinase p38 binding

1 reference

8 April 2019

Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

19 references

8 April 2019

PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

A human protein-protein interaction network: a resource for annotating the proteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Quantitative reactivity profiling predicts functional cysteines in proteomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Arginine methylation of RNA helicase a determines its subcellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Global landscape of HIV-human protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Physical and functional interactions between hnRNP K and PRMT family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

A Y2H-seq approach defines the human protein methyltransferase interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

identical protein binding

IPI

3 references

17 October 2017

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

17 October 2017

A human protein-protein interaction network: a resource for annotating the proteome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

17 October 2017

A Y2H-seq approach defines the human protein methyltransferase interactome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

1 reference

8 April 2019

Arginine methylation of ribosomal protein S3 affects ribosome assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

N-methyltransferase activity

IPI

3 references

8 April 2019

A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Regulation of estrogen rapid signaling through arginine methylation by PRMT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

protein-arginine omega-N asymmetric methyltransferase activity

1 reference

17 October 2017

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

1 reference

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

protein methyltransferase activity

protein-arginine N-methyltransferase activity

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

17 October 2017

Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

17 October 2017

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

1 reference

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

protein methyltransferase activity

HDA

3 references

8 April 2019

FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Arginine methylation of ribosomal protein S3 affects ribosome assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

histone-arginine N-methyltransferase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

protein-arginine N-methyltransferase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

protein-arginine omega-N monomethyltransferase activity

EXP

1 reference

8 April 2019

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

protein-arginine omega-N asymmetric methyltransferase activity

3 references

8 April 2019

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

identical protein binding

4 references

8 April 2019

A human protein-protein interaction network: a resource for annotating the proteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

A Y2H-seq approach defines the human protein methyltransferase interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Novel helical assembly in arginine methyltransferase 8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

S-adenosyl-L-methionine binding

1 reference

8 April 2019

Novel helical assembly in arginine methyltransferase 8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

2 references

1 reference

8 April 2019

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

3 references

8 April 2019

A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Novel helical assembly in arginine methyltransferase 8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

positive regulation of p38MAPK cascade

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

positive regulation of hemoglobin biosynthetic process

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

histone H4-R3 methylation

ISS

1 reference

17 October 2017

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

positive regulation of erythrocyte differentiation

1 reference

8 April 2019

Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

negative regulation of megakaryocyte differentiation

1 reference

8 April 2019

Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

cell surface receptor signaling pathway

1 reference

8 April 2019

A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

peptidyl-arginine methylation

3 references

8 April 2019

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Regulation of estrogen rapid signaling through arginine methylation by PRMT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Arginine methylation of ribosomal protein S3 affects ribosome assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

1 reference

8 April 2019

Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

neuron projection development

1 reference

8 April 2019

PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

peptidyl-arginine N-methylation

1 reference

17 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

1 reference

17 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

regulation of transcription, DNA-templated

TAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

4 references

8 April 2019

Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

Novel helical assembly in arginine methyltransferase 8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

positive regulation of cell population proliferation

1 reference

8 April 2019

FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

regulation of megakaryocyte differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99873&geneProductId=UniProtKB:Q99873

in utero embryonic development

TAS

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

histone arginine methylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

protein homooligomerization

1 reference

8 April 2019

Novel helical assembly in arginine methyltransferase 8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99873

reason for deprecated rank

EC enzyme number

2.1.1.125

deprecated identifier value

1 reference

ENZYME

retrieved

22 April 2020

2.1.1.321

1 reference