Nuclear receptor coactivator 3 (Q21436559)

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mouse protein (annotated by UniProtKB/Swiss-Prot O09000)

SRC-3
Steroid receptor coactivator protein 3
pCIP
Receptor-associated coactivator 3
RAC-3
Thyroid hormone receptor activator molecule 1
ACTR
AIB-1
Amplified in breast cancer-1 protein homolog
TRAM-1
CBP-interacting protein
p/CIP

Language	Label	Description	Also known as
English	Nuclear receptor coactivator 3	mouse protein (annotated by UniProtKB/Swiss-Prot O09000)	SRC-3 Steroid receptor coactivator protein 3 pCIP Receptor-associated coactivator 3 RAC-3 Thyroid hormone receptor activator molecule 1 ACTR AIB-1 Amplified in breast cancer-1 protein homolog TRAM-1 CBP-interacting protein p/CIP

Statements

0 references

PAS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Nuclear receptor coactivator, interlocking

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Nuclear receptor coactivator 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Nuclear receptor coactivator, receptor-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Domain of unknown function DUF4927, protein family

1 reference

based on heuristic

inferred from protein domain or family

PAS fold family

1 reference

based on heuristic

inferred from protein domain or family

Nuclear receptor coactivator, Ncoa-type, interlocking, protein family

1 reference

based on heuristic

inferred from protein domain or family

Domain of unknown function DUF1518, protein family

1 reference

based on heuristic

inferred from protein domain or family

PAS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

molecular function

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

protein dimerization activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

protein N-terminus binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

chromatin binding

determination method

1 reference

14 February 2019

Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

protein binding

determination method

3 references

14 February 2019

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

acyltransferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

RNA polymerase II complex binding

determination method

1 reference

14 February 2019

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

transcription coactivator activity

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

protein heterodimerization activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

disordered domain specific binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

estrogen receptor binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

nuclear receptor coactivator activity

determination method

peroxisome proliferator activated receptor binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

protein-containing complex binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

androgen receptor binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

determination method

2 references

determination method

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

RNA polymerase II transcription regulator complex

determination method

1 reference

14 February 2019

Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

determination method

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09000&geneProductId=UniProtKB:O09000

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09000&geneProductId=UniProtKB:O09000

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09000&geneProductId=UniProtKB:O09000

determination method

24 April 2018

Large-scale identification of mammalian proteins localized to nuclear sub-compartments

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09000&geneProductId=UniProtKB:O09000

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

protein-containing complex

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

Golgi apparatus

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

perinuclear region of cytoplasm

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

Large-scale identification of mammalian proteins localized to nuclear sub-compartments

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

biological process

regulation of RNA biosynthetic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

multicellular organism growth

determination method

1 reference

14 February 2019

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

vagina development

determination method

1 reference

14 February 2019

Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

positive regulation of keratinocyte differentiation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

cellular response to estradiol stimulus

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

mammary gland branching involved in thelarche

determination method

1 reference

14 February 2019

Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

regulation of stem cell population maintenance

determination method

1 reference

14 February 2019

Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09000&geneProductId=UniProtKB:O09000

determination method

negative regulation of stem cell differentiation

determination method

1 reference

14 February 2019

Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

labyrinthine layer morphogenesis

determination method

1 reference

14 February 2019

The Cooperative Function of Nuclear Receptor Coactivator 1 (NCOA1) and NCOA3 in Placental Development and Embryo Survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

cellular response to hormone stimulus

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

developmental growth

determination method

1 reference

14 February 2019

Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

regulation of stem cell proliferation

determination method

1 reference

14 February 2019

Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09000&geneProductId=UniProtKB:O09000

determination method

histone acetylation

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

intracellular receptor signaling pathway

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09000&geneProductId=UniProtKB:O09000

determination method

transcription by RNA polymerase II

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09000&geneProductId=UniProtKB:O09000

determination method

cell dedifferentiation

determination method

1 reference

14 February 2019

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

positive regulation of stem cell population maintenance

determination method

1 reference

14 February 2019

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

positive regulation of cell growth

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

positive regulation of intracellular steroid hormone receptor signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

positive regulation of intracellular estrogen receptor signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

negative regulation of apoptotic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

positive regulation of DNA-binding transcription factor activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

RNA polymerase II preinitiation complex assembly

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09000

determination method

Domain of unknown function DUF1518

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Nuclear receptor coactivator, receptor-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Domain of unknown function DUF4927

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Nuclear receptor coactivator, Ncoa-type, interlocking

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09000

Identifiers

UniProt protein ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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