Zinc finger protein 36 (Q21491046)

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mammalian protein found in Mus musculus
  • TIS11
  • tristetraprolin
  • mRNA decay activator protein ZFP36
  • Zfp-36
  • Zfp36
  • growth factor-inducible nuclear protein NUP475
  • tristetraproline
  • Protein TIS11A
  • TPA-induced sequence 11
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Language Label Description Also known as
English
Zinc finger protein 36
mammalian protein found in Mus musculus
  • TIS11
  • tristetraprolin
  • mRNA decay activator protein ZFP36
  • Zfp-36
  • Zfp36
  • growth factor-inducible nuclear protein NUP475
  • tristetraproline
  • Protein TIS11A
  • TPA-induced sequence 11

Statements

molecular function
protein binding
determination method
IPI
6 references
retrieved
8 April 2019
stated in
Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IPI
retrieved
8 April 2019
stated in
MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IPI
retrieved
8 April 2019
stated in
Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IPI
retrieved
8 April 2019
stated in
Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IPI
retrieved
8 April 2019
stated in
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IPI
retrieved
8 April 2019
stated in
Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IPI
mRNA 3'-UTR AU-rich region binding
determination method
IDA
ISO
9 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISO
retrieved
8 April 2019
stated in
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
cell component
cytoplasm
determination method
IDA
ISS
IEA
ISO
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISO
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IEA
retrieved
8 April 2019
stated in
Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
nucleus
determination method
IDA
ISS
IEA
ISO
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISO
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IEA
retrieved
8 April 2019
stated in
Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
biological process
cellular response to lipopolysaccharide
determination method
IDA
IMP
ISO
ISS
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISO
retrieved
8 April 2019
stated in
Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IMP
retrieved
8 April 2019
stated in
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
3'-UTR-mediated mRNA destabilization
determination method
IBA
IDA
IMP
ISO
ISS
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
ISO
retrieved
8 April 2019
stated in
Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IMP
retrieved
8 April 2019
stated in
Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes
GOA
curator
UniProt
UniProt protein ID
P22893
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22893
determination method
IBA

Identifiers

 
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