Estrogen related receptor, beta (Q21494398)

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mammalian protein found in Mus musculus

estrogen receptor related 2
estrogen receptor-like 2
ERR-beta
steroid hormone receptor ERR2
Esrrb
nuclear receptor subfamily 3 group B member 2
Estrogen-related receptor beta

Language	Label	Description	Also known as
English	Estrogen related receptor, beta	mammalian protein found in Mus musculus	estrogen receptor related 2 estrogen receptor-like 2 ERR-beta steroid hormone receptor ERR2 Esrrb nuclear receptor subfamily 3 group B member 2 Estrogen-related receptor beta

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Nuclear hormone receptor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61539

Zinc finger, NHR/GATA-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61539

oestrogen-related receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61539

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

steroid hormone receptor activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

24 April 2018

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61539&geneProductId=UniProtKB:Q61539

determination method

determination method

2 references

transcription coactivator activity

determination method

1 reference

10 September 2018

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61539&geneProductId=UniProtKB:Q61539

determination method

zinc ion binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

steroid binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

transcription factor binding

determination method

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

protein binding

determination method

8 references

14 February 2019

Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Dax1 associates with Esrrb and regulates its function in embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

An Oct4-centered protein interaction network in embryonic stem cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

DNA-binding transcription factor activity

determination method

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Dax1 associates with Esrrb and regulates its function in embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

RNA polymerase II complex binding

determination method

1 reference

14 February 2019

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

cis-regulatory region sequence-specific DNA binding

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

11 October 2018

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61539&geneProductId=UniProtKB:Q61539

determination method

sequence-specific DNA binding

determination method

6 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

14 February 2019

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding

determination method

1 reference

11 October 2018

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61539&geneProductId=UniProtKB:Q61539

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Efferent retinal projections visualized by immunohistochemical detection of the estrogen-related receptor beta in the postnatal and adult mouse brain.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

condensed chromosome

determination method

1 reference

14 February 2019

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

integrator complex

determination method

1 reference

14 February 2019

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

biological process

embryonic placenta development

determination method

1 reference

14 February 2019

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

in utero embryonic development

determination method

1 reference

14 February 2019

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

regulation of transcription, DNA-templated

determination method

3 references

trophectodermal cell proliferation

determination method

1 reference

14 February 2019

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

transcription, DNA-templated

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61539&geneProductId=UniProtKB:Q61539

determination method

steroid hormone mediated signaling pathway

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

trophectodermal cellular morphogenesis

determination method

1 reference

14 February 2019

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

transcription by RNA polymerase II

determination method

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61539&geneProductId=UniProtKB:Q61539

determination method

stem cell division

determination method

cell dedifferentiation

determination method

1 reference

14 February 2019

Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

positive regulation of stem cell population maintenance

determination method

4 references

14 February 2019

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

regulation of stem cell division

determination method

photoreceptor cell maintenance

determination method

1 reference

14 February 2019

The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

positive regulation of transcription, DNA-templated

determination method

positive regulation of transcription involved in G1/S transition of mitotic cell cycle

determination method

1 reference

14 February 2019

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

positive regulation of transcription involved in G2/M transition of mitotic cell cycle

determination method

1 reference

14 February 2019

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

negative regulation of stem cell differentiation

determination method

1 reference

14 February 2019

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

inner ear development

determination method

1 reference

14 February 2019

Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61539&geneProductId=UniProtKB:Q61539

determination method

stem cell population maintenance

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Mediator and cohesin connect gene expression and chromatin architecture

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Dissecting self-renewal in stem cells with RNA interference

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

14 February 2019

Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

cell population proliferation

determination method

2 references

positive regulation of glycolytic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61539

determination method

Nuclear hormone receptor, ligand-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61539

nuclear hormone receptor-type zinc finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61539

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000021680

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000021680

ENSMUSP00000131335

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000131335

ENSMUSP00000105832

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105832

ENSMUSP00000105833

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105833

ENSMUSP00000112103

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000112103

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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