Arachidonate 15-lipoxygenase (Q21494713)

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mammalian protein found in Mus musculus

arachidonate 15-lipoxygenase
Alox15
arachidonate 12-lipoxygenase, leukocyte-type
hepoxilin A3 synthase Alox15
polyunsaturated fatty acid lipoxygenase ALOX15
12-LOX
12/15-lipoxygenase
1.13.11.31
linoleate 13S-lipoxygenase
12/15-LO
arachidonate omega-6 lipoxygenase
L-12LO

Language	Label	Description	Also known as
English	Arachidonate 15-lipoxygenase	mammalian protein found in Mus musculus	arachidonate 15-lipoxygenase Alox15 arachidonate 12-lipoxygenase, leukocyte-type hepoxilin A3 synthase Alox15 polyunsaturated fatty acid lipoxygenase ALOX15 12-LOX 12/15-lipoxygenase 1.13.11.31 linoleate 13S-lipoxygenase 12/15-LO arachidonate omega-6 lipoxygenase L-12LO

Statements

1 reference

25 May 2022

UniProt protein ID

Lipoxigenase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P39654

PLAT/LH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P39654

Lipoxygenase, mammalian

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P39654

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Lipoxygenase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, iron binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLAT/LH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

iron ion binding

determination method

2 references

arachidonate 12(S)-lipoxygenase activity

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

dioxygenase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

metal ion binding

determination method

2 references

arachidonate 15-lipoxygenase activity

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

oxidoreductase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

phosphatidylinositol-4,5-bisphosphate binding

determination method

3 references

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

extrinsic component of cytoplasmic side of plasma membrane

determination method

3 references

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

biological process

cellular response to calcium ion

determination method

3 references

bone mineralization

determination method

1 reference

14 February 2019

Regulation of bone mass in mice by the lipoxygenase gene Alox15

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

positive regulation of actin filament polymerization

determination method

1 reference

14 February 2019

12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

negative regulation of adaptive immune response

determination method

1 reference

14 February 2019

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

determination method

1 reference

14 February 2019

Regulation of bone mass in mice by the lipoxygenase gene Alox15

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

lipoxin A4 biosynthetic process

determination method

1 reference

14 February 2019

A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

lipid metabolism

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

determination method

1 reference

14 February 2019

A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

phosphatidylethanolamine biosynthetic process

determination method

1 reference

14 February 2019

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

regulation of peroxisome proliferator activated receptor signaling pathway

determination method

1 reference

14 February 2019

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

response to endoplasmic reticulum stress

determination method

1 reference

14 February 2019

12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

fatty acid metabolic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

apoptotic cell clearance

determination method

1 reference

14 February 2019

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

lipoxygenase pathway

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

regulation of engulfment of apoptotic cell

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

3 references

arachidonic acid metabolic process

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

14 February 2019

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39654

determination method

cellular response to interleukin-13

determination method

3 references

positive regulation of cell-substrate adhesion

determination method

3 references

hepoxilin biosynthetic process

determination method

3 references

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000019068

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000019068

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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