Apoptosis-inducing factor, mitochondrion-associated 1 (Q21494811)

FAD/NAD(P)-binding domain superfamily

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

FAD/NAD(P)-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Mitochondrial apoptosis-inducing factor, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

NAD(P)H oxidase H2O2-forming activity

1 reference

14 February 2019

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

protein dimerization activity

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

flavin adenine dinucleotide binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

1 reference

14 February 2019

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

3 references

14 February 2019

Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Multiple TSC22D4 iso-/phospho-glycoforms display idiosyncratic subcellular localizations and interacting protein partners

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

electron-transferring-flavoprotein dehydrogenase activity

IPI

1 reference

14 February 2019

Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

oxidoreductase activity

2 references

1 reference

14 February 2019

mitochondrial intermembrane space

5 references

14 February 2019

Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

mitochondrial outer membrane

1 reference

14 February 2019

Molecular Components of a Cell Death Pathway Activated by Endoplasmic Reticulum Stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

11 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

perinuclear region of cytoplasm

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

mitochondrial inner membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

4 references

10 October 2017

Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

3 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

10 October 2017

TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

5 references

14 February 2019

Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

14 February 2019

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms

IDA

biological process

neuron apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

cellular response to aldosterone

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

positive regulation of cell death

1 reference

14 February 2019

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

cellular response to estradiol stimulus

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

response to oxidative stress

1 reference

14 February 2019

No death without life: vital functions of apoptotic effectors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

14 February 2019

Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

apoptotic mitochondrial changes

1 reference

14 February 2019

Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

response to L-glutamate

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

positive regulation of apoptotic process

1 reference

14 February 2019

No death without life: vital functions of apoptotic effectors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

cellular response to nitric oxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

regulation of apoptotic DNA fragmentation

1 reference

14 February 2019

Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

activation of cysteine-type endopeptidase activity involved in apoptotic process

IGI

3 references

cellular response to oxygen-glucose deprivation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

response to toxic substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

cellular response to hydrogen peroxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

3 references

positive regulation of neuron apoptotic process

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0X1&geneProductId=UniProtKB:Q9Z0X1

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

mitochondrial respiratory chain complex I assembly

ISO

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

respiratory electron transport chain

ISO

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0X1

FAD/NAD(P)-binding domain

has part(s)

1 reference

Mitochondrial apoptosis-inducing factor, C-terminal domain

1 reference