Chemokine (C-C motif) receptor 2 (Q21495023)

http://www.ebi.ac.uk/interpro/protein/P51683

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

chemokine (C-C motif) ligand 12 binding

1 reference

1 January 2018

Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

protein homodimerization activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

signal transducer activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

chemokine receptor activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

chemokine (C-C motif) ligand 7 binding

1 reference

1 January 2018

Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

C-C chemokine receptor activity

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

27 March 2018

Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

27 March 2018

Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

chemokine (C-C motif) ligand 2 binding

1 reference

1 January 2018

Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

CCR2 chemokine receptor binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

C-C chemokine receptor activity

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

C-C chemokine binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

chemokine (C-C motif) ligand 5 binding

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

integral component of plasma membrane

1 reference

1 January 2018

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

perinuclear region of cytoplasm

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

external side of plasma membrane

1 reference

27 March 2018

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of inflammatory response

biological process

1 reference

1 January 2018

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

regulation of cell migration

3 references

1 January 2018

CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 c

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of immune complex clearance by monocytes and macrophages

1 reference

1 January 2018

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of T-helper 1 cell differentiation

1 reference

1 January 2018

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

chemokine-mediated signaling pathway

IC

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

negative regulation of eosinophil degranulation

1 reference

1 January 2018

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of monocyte chemotaxis

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of interferon-gamma production

1 reference

1 January 2018

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of CD8-positive, alpha-beta T cell extravasation

1 reference

1 January 2018

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

cellular calcium ion homeostasis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of hematopoietic stem cell migration

1 reference

1 January 2018

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

T-helper 17 cell chemotaxis

1 reference

1 January 2018

Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

wound healing involved in inflammatory response

1 reference

1 January 2018

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC

NAS

apoptotic cell clearance

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

cellular defense response

1 reference

1 January 2018

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of T cell activation

1 reference

1 January 2018

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of monocyte extravasation

1 reference

1 January 2018

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 c

humoral immune response

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of T-helper 1 type immune response

1 reference

1 January 2018

CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of interleukin-2 production

1 reference

1 January 2018

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of T cell chemotaxis

1 reference

1 January 2018

Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

Generation, characterization and biological activity of CCL2 (MCP-1/JE) and CCL12 (MCP-5) specific antibodies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

4 references

27 March 2018

Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

27 March 2018

CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

27 March 2018

Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of alpha-beta T cell proliferation

1 reference

1 January 2018

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

regulation of vascular endothelial growth factor production

1 reference

1 January 2018

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

negative regulation of type 2 immune response

1 reference

1 January 2018

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

negative regulation of angiogenesis

1 reference

1 January 2018

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

sensory perception of pain

1 reference

1 January 2018

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of leukocyte tethering or rolling

1 reference

1 January 2018

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

leukocyte adhesion to vascular endothelial cell

1 reference

1 January 2018

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

homeostasis of number of cells within a tissue

1 reference

1 January 2018

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

cytokine-mediated signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of astrocyte chemotaxis

1 reference

1 January 2018

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice

inflammatory response

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

5 references

1 January 2018

CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of cytosolic calcium ion concentration

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

calcium-mediated signaling

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

positive regulation of cold-induced thermogenesis

1 reference

1 January 2018

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51683&geneProductId=UniProtKB:P51683

GPCR, rhodopsin-like, 7TM

has part(s)

1 reference

stated in

InterPro Release 71.0