Inositol 1,4,5-trisphosphate receptor 1 (Q21495559)

Mir domain superfamily

1 reference

inositol 1,4,5-trisphosphate receptors

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain, protein family

1 reference

Ion transport domain, protein family

1 reference

MIR motif domain, protein family

1 reference

RyR/IP3R Homology associated domain, protein family

1 reference

RIH domain, protein family

1 reference

The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage

1 reference

25 May 2022

1 reference

25 May 2022

16 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

phosphatidylinositol binding

3 references

24 April 2018

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

24 April 2018

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

24 April 2018

Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

calcium-release channel activity

1 reference

14 February 2019

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

calcium channel activity

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

inositol 1,4,5 trisphosphate binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

5 references

24 April 2018

The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

24 April 2018

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

24 April 2018

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

protein C-terminus binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

protein phosphatase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

6 references

14 February 2019

The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

phosphatidylinositol binding

4 references

14 February 2019

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

nuclear inner membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

transport vesicle membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner

endoplasmic reticulum

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

endoplasmic reticulum membrane

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

24 April 2018

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

secretory granule membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

intracellular membrane-bounded organelle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

perinuclear region of cytoplasm

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

endoplasmic reticulum membrane

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

sarcoplasmic reticulum

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

integral component of endoplasmic reticulum membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

cytoplasmic vesicle membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

smooth endoplasmic reticulum membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

integral component of organelle membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

endoplasmic reticulum calcium ion homeostasis

biological process

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

2 references

voluntary musculoskeletal movement

1 reference

14 February 2019

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

calcium ion transmembrane transport

IMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

2 references

transmembrane transport

1 reference

14 February 2019

epithelial fluid transport

1 reference

14 February 2019

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

14 February 2019

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

post-embryonic development

IMP

1 reference

14 February 2019

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

calcium ion transport

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

inositol phosphate-mediated signaling

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

positive regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

positive regulation of calcium ion transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

cellular response to cAMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

negative regulation of neuron death

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

positive regulation of neuron projection development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

positive regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

release of sequestered calcium ion into cytosol

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

protein homotetramerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

regulation of postsynaptic cytosolic calcium ion concentration

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

positive regulation of hepatocyte proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881

RyR/IP3R Homology associated domain

has part(s)

1 reference

RIH domain

1 reference

MIR motif

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain

1 reference

Ion transport domain

1 reference