Homeodomain interacting protein kinase 2 (Q21495855)

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

1 reference

14 February 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

protein kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

transcription corepressor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

8 references

14 February 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

2 references

protein serine/threonine kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Estrogenic induction of spermatogenesis in the hypogonadal mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

4 references

14 February 2019

Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

RNA polymerase II transcription regulator complex

1 reference

14 February 2019

Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

negative regulation of neuron apoptotic process

biological process

1 reference

14 February 2019

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

positive regulation of transforming growth factor beta receptor signaling pathway

3 references

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

14 February 2019

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

positive regulation of protein phosphorylation

1 reference

14 February 2019

Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

regulation of transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZR5&geneProductId=UniProtKB:Q9QZR5

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

retina layer formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

voluntary musculoskeletal movement

1 reference

14 February 2019

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

1 reference

14 February 2019

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

adult locomotory behavior

1 reference

14 February 2019

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

positive regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

positive regulation of JNK cascade

3 references

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZR5&geneProductId=UniProtKB:Q9QZR5

cellular response to DNA damage stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

protein phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

14 February 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

embryonic camera-type eye morphogenesis

1 reference

14 February 2019

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

peptidyl-serine phosphorylation

1 reference

14 February 2019

Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

lens induction in camera-type eye

1 reference

14 February 2019

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

positive regulation of cell population proliferation

1 reference

14 February 2019

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

embryonic retina morphogenesis in camera-type eye

1 reference

14 February 2019

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

smoothened signaling pathway

1 reference

14 February 2019

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

positive regulation of DNA binding

1 reference

14 February 2019

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

positive regulation of protein binding

1 reference

14 February 2019

Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

peptidyl-threonine phosphorylation

1 reference

14 February 2019

Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

transforming growth factor beta receptor signaling pathway

1 reference

14 February 2019

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

anterior/posterior pattern specification

1 reference

14 February 2019

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

adult walking behavior

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZR5

transcription by RNA polymerase II

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZR5&geneProductId=UniProtKB:Q9QZR5

serine/threonine-protein kinase, active site

has part(s)

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference