Interleukin 1 receptor, type I (Q21495868)

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mammalian protein found in Mus musculus

IL-1 receptor alpha chain
interleukin-1 receptor alpha
p80
IL-1RT1
Il1r1
CD121 antigen-like family member A
IL-1R-alpha
interleukin-1 receptor type 1
IL-1RT-1
Interleukin-1 receptor type I
IL-1R-1

Language	Label	Description	Also known as
English	Interleukin 1 receptor, type I	mammalian protein found in Mus musculus	IL-1 receptor alpha chain interleukin-1 receptor alpha p80 IL-1RT1 Il1r1 CD121 antigen-like family member A IL-1R-alpha interleukin-1 receptor type 1 IL-1RT-1 Interleukin-1 receptor type I IL-1R-1

Statements

1 reference

25 May 2022

UniProt protein ID

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13504

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13504

interleukin-1 receptor type 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13504

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13504

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

interleukin-1, type I, activating receptor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

signal transducer activity

determination method

1 reference

24 April 2018

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13504&geneProductId=UniProtKB:P13504

determination method

protease binding

determination method

1 reference

9 May 2019

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

protein binding

determination method

4 references

9 May 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

9 May 2019

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

9 May 2019

MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

9 May 2019

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

interleukin-1 receptor activity

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

14 February 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

14 February 2019

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

interleukin-1 binding

determination method

1 reference

14 February 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

ionotropic glutamate receptor binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

interleukin-1 receptor activity

determination method

6 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

9 May 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

9 May 2019

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

integral component of membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

plasma membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

extracellular region

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

external side of plasma membrane

determination method

1 reference

9 May 2019

The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

extracellular space

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

postsynaptic density

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

protein-containing complex

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

biological process

cytokine-mediated signaling pathway

determination method

regulation of inflammatory response

determination method

1 reference

14 February 2019

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

signal transduction

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

positive regulation of interleukin-1-mediated signaling pathway

determination method

1 reference

9 May 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

positive regulation of neutrophil extravasation

determination method

1 reference

9 May 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

response to radiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

heat acclimation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

positive regulation of neuron migration

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

inflammatory response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13504

determination method

positive regulation of interferon-gamma production

determination method

positive regulation of T-helper 1 cell cytokine production

determination method

interleukin-1-mediated signaling pathway

determination method

immunoglobulin subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13504

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13504

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13504

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000027241

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000027241

ENSMUSP00000110443

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000110443

PDB structure ID

1 reference

16 November 2015

http://www.uniprot.org/uniprot/P13504.txt?version=159

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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