TLE family member 5, transcriptional modulator (Q21496856)

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mammalian protein found in Mus musculus

related to Drosophila groucho
Grg-5
Protein GRG
groucho-related protein 5
TLE family member 5
Protein ESP1
Tle5
amino-terminal enhancer of split
Aes

Language	Label	Description	Also known as
English	TLE family member 5, transcriptional modulator	mammalian protein found in Mus musculus	related to Drosophila groucho Grg-5 Protein GRG groucho-related protein 5 TLE family member 5 Protein ESP1 Tle5 amino-terminal enhancer of split Aes

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Groucho/transducin-like enhancer

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63002

Groucho/TLE, N-terminal Q-rich domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method or standard

3 references

8 April 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

transcription corepressor activity

determination method or standard

3 references

21 June 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

21 June 2018

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

identical protein binding

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

transcription corepressor activity

determination method or standard

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

transcription corepressor activity

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

14 February 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

determination method or standard

6 references

21 June 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

21 June 2018

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

21 June 2018

The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

21 June 2018

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

determination method or standard

8 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

transcription regulator complex

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

biological process

regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

cellular response to extracellular stimulus

determination method or standard

1 reference

8 April 2019

Screen for genes regulated during early kidney morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

skeletal system development

determination method or standard

1 reference

8 April 2019

Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

regulation of growth

determination method or standard

1 reference

8 April 2019

Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

Wnt signaling pathway

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63002&geneProductId=UniProtKB:P63002

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

negative regulation of canonical Wnt signaling pathway

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

negative regulation of gene expression

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

negative regulation of protein binding

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

negative regulation of response to cytokine stimulus

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

response to interleukin-1

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

positive regulation of anoikis

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63002

determination method or standard

Groucho/TLE, N-terminal Q-rich domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63002

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000002518

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000002518

ENSMUSP00000151523

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000151523

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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