Cathepsin D (Q21499226)

Cathepsin D

1 reference

Peptidase family A1 domain

1 reference

based on heuristic

inferred from protein domain or family

Aspartic peptidase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aspartic peptidase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

8 April 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

8 April 2019

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

aspartic-type endopeptidase activity

IDA

aspartic-type endopeptidase activity

IDA

IEA

3 references

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Regulated renin release from 3T3-L1 adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

1 reference

9 May 2019

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

aspartic-type peptidase activity

IPI

1 reference

9 May 2019

Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

11 references

27 February 2018

Identification and subcellular localization of a new cystinosin isoform

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Identification and subcellular localization of a new cystinosin isoform

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

1 reference

27 February 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

1 reference

9 May 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

13 references

9 May 2019

Identification and subcellular localization of a new cystinosin isoform

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Identification and subcellular localization of a new cystinosin isoform

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

collagen-containing extracellular matrix

IBA

1 reference

9 May 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

protein catabolic process

biological process

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

epithelial tube branching involved in lung morphogenesis

IBA

1 reference

9 May 2019

Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

IMP

autophagosome assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

27 February 2018

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18242&geneProductId=UniProtKB:P18242

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

lipoprotein catabolic process

IBA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

positive regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

regulation of establishment of protein localization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18242

Aspartic peptidase, N-terminal

has part(s)

1 reference

Peptidase family A1 domain

1 reference

Aspartic peptidase, active site

1 reference