Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling (Q21559447)

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English	Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling	scientific article

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Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling (English)

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traumatic brain injury

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author name string

Chun-Hu Wu

1

author given names

Chun-Hu

author last names

Wu

1 reference

12 September 2022

Tai-Ho Hung

2

author given names

Tai-Ho

author last names

Hung

1 reference

12 September 2022

Chien-Cheng Chen

3

author given names

Chien-Cheng

author last names

Chen

1 reference

12 September 2022

Chia-Hua Ke

4

author given names

Chia-Hua

author last names

Ke

1 reference

12 September 2022

Chun-Yen Lee

5

author given names

Chun-Yen

author last names

Lee

1 reference

12 September 2022

Pei-Yi Wang

6

author given names

Pei-Yi

author last names

Wang

1 reference

12 September 2022

Szu-Fu Chen

7

author given names

Szu-Fu

author last names

Chen

1 reference

12 September 2022

language of work or name

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publication date

2014

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9

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11

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e113397

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copyright license

Creative Commons Attribution 4.0 International

21 November 2014

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April 2022 Public Data File from Crossref

copyright status

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4240709/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

19 March 2017

Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

19 March 2017

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

19 March 2017

Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

19 March 2017

Function and regulation of CREB family transcription factors in the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

7 April 2017

Neurodegenerative disorders: dysregulation of a carefully maintained balance?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Engineering of bacteria for the visualization of targeted delivery of a cytolytic anticancer agent

1 reference

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12 September 2017

Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-κB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Early nonischemic oxidative metabolic dysfunction leads to chronic brain atrophy in traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

BDNF function and intracellular signaling in neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Edema and brain trauma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Oxidative neuronal injury. The dark side of ERK1/2.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Pathophysiology of cerebral ischemia and brain trauma: similarities and differences

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

12 September 2017

Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

27 September 2017

Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

27 September 2017

Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

27 September 2017

Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

30 May 2018

Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Expression of trkB mRNA is altered in rat hippocampus after experimental brain trauma.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Time course of cellular pathology after controlled cortical impact injury.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Beam-walking in rats: studies towards developing an animal model of functional recovery after brain injury.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Alteration in BDNF and its receptors, full-length and truncated TrkB and p75(NTR) following penetrating traumatic brain injury

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

The role of p75NTR in modulating neurotrophin survival effects in developing motoneurons.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

Thyroxin treatment protects against white matter injury in the immature brain via brain-derived neurotrophic factor

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0113397

21 January 2018

7,8-Dihydroxyflavone leads to survival of cultured embryonic motoneurons by activating intracellular signaling pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

29 November 2018

Stretch-induced injury alters mitochondrial membrane potential and cellular ATP in cultured astrocytes and neurons

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240709

29 November 2018

Motor impairment after severe traumatic brain injury: A longitudinal multicenter study

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https://pubmed.ncbi.nlm.nih.gov/25415296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities

1 reference

https://pubmed.ncbi.nlm.nih.gov/25415296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in trkB-ERK1/2-CREB/Elk-1 pathways in hippocampal mossy fiber organization after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/25415296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0113397

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2014PLoSO...9k3397W

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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