A Novel Prolyl Endopeptidase Inhibitor, JTP-4819 - Its Behavioral and Neurochemical Properties for the Treatment of Alzheimer's Disease (Q21651042)

2

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Akira Miyazaki

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K Toide

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M Shinoda

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A Miyazaki

Reviews in the Neurosciences

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language of work or name

English

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publication date

January 1998

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1998

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published in

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Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease.

volume

9

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issue

1

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page(s)

17-29

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cites work

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

In vitro and in vivo inhibition of prolyl endopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Expression of amyloid precursor protein in a neuronal cell line: functional activity of proximal regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Cortical substance P-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Central target for the behavioural effects of vasopressin neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Pharmacological strategies in CNS trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Neuropeptides in Alzheimer type dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Reduction of arginine-vasopressin in the cerebral cortex in Alzheimer type senile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Thyrotrophin-releasing hormone inactivation by human postmortem brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Neuropeptide substance P improves water maze performance in aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

The role of neuropeptides in learning: focus on the neurokinin substance P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Brain cholinergic dysfunction and memory in aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Vasopressin in Alzheimer's disease: a study of postmortem brain concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Spatial localization does not require the presence of local cues

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Modulation of Synapse Formation by Cyclic Adenosine Monophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Purification and characterization of a novel membrane-bound form of prolyl endopeptidase from bovine brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Taking stock of cognition enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Substance P enhancement of passive and active avoidance conditioning in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Specific inhibitor for prolyl endopeptidase suppresses the generation of amyloid beta protein in NG108-15 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

ZTTA, a postproline cleaving enzyme inhibitor, improves cerebral ischemia-induced deficits in a three-panel runway task in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

CSF and plasma vasopressin concentrations in dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and central cholinergic neurons in aged rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Pharmacokinetics and safety of JTP-4819, a novel specific orally active prolyl endopeptidase inhibitor, in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Leucylglycinamide Released from Oxytocin by Human Uterine Enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Effects of bilateral ibotenate-induced lesions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Behavioral changes after focal cerebral ischemia by left middle cerebral artery occlusion in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

Distribution of post-proline cleaving enzyme in human brain and the peripheral tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Proline specific endo- and exopeptidases

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Post-proline cleaving enzyme. Synthesis of a new fluorogenic substrate and distribution of the endopeptidase in rat tissues and body fluids of man

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Catabolism of neuropeptides by a brain proline endopeptidase

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Clinical applications of thyrotrophin-releasing hormone

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Influence of region-specific alterations of neuropeptidase content on the catabolic fates of neuropeptides in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on prolyl endopeptidase activity and substance P- and arginine-vasopressin-like immunoreactivity in the brains of aged rats.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Differentiation of NG108-15 neuroblastoma cells by serum starvation or dimethyl sulfoxide results in marked differences in angiotensin II receptor subtype expression

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Prolyl Endopeptidase from Flavobacterium meningosepticum: Cloning and Sequencing of the Enzyme Gene1

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Molecular cloning and characterization of prolyl endopeptidase from human T cells.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Post-Proline Cleaving Enzyme (Prolyl Endoeptidase) from Bovine Brain1

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Identification and Localization of a Synaptosomal Membrane Prolyl Endopeptidase from Bovine Brain

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Investigation of cerebrospinal fluid neuropeptides in idiopathic senile dementia

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Disturbance of retention of memory after focal cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Substance P-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021

Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired.

1 reference

https://api.crossref.org/works/10.1515%2FREVNEURO.1998.9.1.17

7 January 2021