Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (Q21980330)

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mammalian protein found in Mus musculus

low density lipoprotein receptor relative, 8 ligand binding repeats, brain
low-density lipoprotein receptor-related protein 8
Lrp8
apolipoprotein E receptor 2

Language	Label	Description	Also known as
English	Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	mammalian protein found in Mus musculus	low density lipoprotein receptor relative, 8 ligand binding repeats, brain low-density lipoprotein receptor-related protein 8 Lrp8 apolipoprotein E receptor 2

Statements

1 reference

10 April 2019

UniProt protein ID

LDL receptor-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

Six-bladed beta-propeller, TolB-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

Putative uncharacterized transport proteins

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

LDLR class B repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

10 April 2019

UniProt protein ID

1 reference

10 April 2019

UniProt protein ID

molecular function

very-low-density lipoprotein particle receptor activity

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

calcium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

calcium-dependent protein binding

determination method

1 reference

8 April 2019

Reelin is a ligand for lipoprotein receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

apolipoprotein binding

determination method

1 reference

8 April 2019

Reelin is a ligand for lipoprotein receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

reelin receptor activity

determination method

protein binding

determination method

6 references

8 April 2019

Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

8 April 2019

F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

8 April 2019

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

8 April 2019

Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

8 April 2019

Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

8 April 2019

Reelin is a ligand for lipoprotein receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

high-density lipoprotein particle binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

kinesin binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

amyloid-beta binding

determination method

1 reference

8 April 2019

F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

protein N-terminus binding

determination method

1 reference

8 April 2019

F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

receptor complex

determination method

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

extracellular region

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

extracellular space

determination method

1 reference

8 April 2019

Regulation of ApoE receptor proteolysis by ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

microtubule associated complex

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

postsynaptic density

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

determination method

1 reference

8 April 2019

F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

biological process

chemical synaptic transmission

determination method

1 reference

8 April 2019

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

dendrite morphogenesis

determination method

1 reference

8 April 2019

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

hippocampus development

determination method

1 reference

8 April 2019

The Pafah1b complex interacts with the reelin receptor VLDLR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

positive regulation of dendrite development

determination method

1 reference

8 April 2019

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

positive regulation of protein tyrosine kinase activity

determination method

1 reference

8 April 2019

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

layer formation in cerebral cortex

determination method

1 reference

8 April 2019

The Pafah1b complex interacts with the reelin receptor VLDLR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

modulation of chemical synaptic transmission

determination method

1 reference

8 April 2019

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

ammon gyrus development

determination method

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

8 April 2019

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

positive regulation of CREB transcription factor activity

determination method

1 reference

8 April 2019

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

positive regulation of dendritic spine morphogenesis

determination method

positive regulation of protein kinase activity

determination method

1 reference

8 April 2019

Reelin activates SRC family tyrosine kinases in neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

ventral spinal cord development

determination method

1 reference

8 April 2019

Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

receptor-mediated endocytosis

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

regulation of apoptotic process

determination method

1 reference

8 April 2019

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

regulation of innate immune response

determination method

1 reference

8 April 2019

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924X6

determination method

EGF-like calcium-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

low-density lipoprotein (LDL) receptor class A repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

LDLR class B repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

EGF-type aspartate/asparagine hydroxylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924X6

Identifiers

RefSeq protein ID

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

16 August 2019

1 reference

16 August 2019

1 reference

16 August 2019

1 reference

16 August 2019

1 reference

16 August 2019

1 reference

16 August 2019

1 reference

16 August 2019

1 reference

16 August 2019

UniProt protein ID

1 reference

10 April 2019

UniProt protein ID

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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