Fibroblast growth factor receptor substrate 2 (Q21981375)

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mammalian protein found in Mus musculus

fibroblast growth factor receptor substrate 2
Frs2
FRS2-alpha
SNT-1
FGFR substrate 2
suc1-associated neurotrophic factor target 1
FGFR-signaling adaptor SNT

Language	Label	Description	Also known as
English	Fibroblast growth factor receptor substrate 2	mammalian protein found in Mus musculus	fibroblast growth factor receptor substrate 2 Frs2 FRS2-alpha SNT-1 FGFR substrate 2 suc1-associated neurotrophic factor target 1 FGFR-signaling adaptor SNT

Statements

1 reference

25 May 2022

UniProt protein ID

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

FRS2, PTB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

IRS-type PTB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transmembrane receptor protein tyrosine kinase adaptor activity

determination method or standard

1 reference

14 February 2019

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

protein binding

determination method or standard

4 references

14 February 2019

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

14 February 2019

Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

14 February 2019

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

14 February 2019

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

determination method or standard

2 references

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

plasma membrane

determination method or standard

2 references

cell-cell junction

determination method or standard

1 reference

14 February 2019

The Role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

biological process

regulation of apoptotic process

determination method or standard

1 reference

14 February 2019

The Role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

ventricular septum development

determination method or standard

1 reference

14 February 2019

Generation of an Frs2alpha conditional null allele

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

organ induction

determination method or standard

1 reference

14 February 2019

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

transmembrane receptor protein tyrosine kinase signaling pathway

determination method or standard

1 reference

14 February 2019

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

gastrulation with mouth forming second

determination method or standard

1 reference

14 February 2019

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

lens placode formation involved in camera-type eye formation

determination method or standard

1 reference

14 February 2019

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

fibroblast growth factor receptor signaling pathway

determination method or standard

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

14 February 2019

Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

14 February 2019

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

14 February 2019

Generation of an Frs2alpha conditional null allele

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

lens development in camera-type eye

determination method or standard

1 reference

14 February 2019

Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

determination method or standard

1 reference

14 February 2019

Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

14 February 2019

The Role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

neuroblast proliferation

determination method or standard

2 references

forebrain development

determination method or standard

1 reference

14 February 2019

Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

regulation of epithelial cell proliferation

determination method or standard

1 reference

14 February 2019

Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

anterior/posterior axis specification, embryo

determination method or standard

1 reference

14 February 2019

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

lens fiber cell development

determination method or standard

cellular response to fibroblast growth factor stimulus

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

positive regulation of vascular associated smooth muscle cell proliferation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C180

determination method or standard

IRS-type PTB domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8C180

FRS2, PTB domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8C180

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

1 reference

18 June 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000020381

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000020381

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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