Suppressor of variegation 3-9 1 (Q21981394)

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mammalian protein found in Mus musculus

position-effect variegation 3-9 homolog
H3-K9-HMTase 1
Suv39h histone methyltransferase
su(var)3-9 homolog 1
histone-lysine N-methyltransferase SUV39H1
suppressor of variegation 3-9 homolog 1
histone H3-K9 methyltransferase 1
Suv39h1

Language	Label	Description	Also known as
English	Suppressor of variegation 3-9 1	mammalian protein found in Mus musculus	position-effect variegation 3-9 homolog H3-K9-HMTase 1 Suv39h histone methyltransferase su(var)3-9 homolog 1 histone-lysine N-methyltransferase SUV39H1 suppressor of variegation 3-9 homolog 1 histone H3-K9 methyltransferase 1 Suv39h1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Histone H3-K9 methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54864

Chromo-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54864

Chromo domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Post-SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Chromo/chromo shadow domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pre-SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Chromo domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

histone methyltransferase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

histone methyltransferase activity (H3-K9 specific)

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

S-adenosylmethionine-dependent methyltransferase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

protein N-terminus binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

zinc ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

transcription cis-regulatory region binding

determination method

1 reference

9 May 2019

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

histone-lysine N-methyltransferase activity

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Regulation of chromatin structure by site-specific histone H3 methyltransferases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

protein binding

determination method

7 references

9 May 2019

A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

protein methyltransferase activity

determination method

1 reference

9 May 2019

Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

histone methyltransferase activity (H3-K9 specific)

determination method

3 references

9 May 2019

Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

rDNA heterochromatin

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

chromosome, centromeric region

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

14 February 2019

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

14 February 2019

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

determination method

6 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

biological process

cell differentiation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

regulation of transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54864&geneProductId=UniProtKB:O54864

determination method

histone H3-K9 dimethylation

determination method

1 reference

9 May 2019

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

rhythmic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

negative regulation of circadian rhythm

determination method

1 reference

9 May 2019

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54864&geneProductId=UniProtKB:O54864

determination method

histone H3-K9 trimethylation

determination method

1 reference

9 May 2019

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

cellular response to DNA damage stimulus

determination method

1 reference

9 May 2019

Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

rDNA heterochromatin assembly

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

rRNA processing

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

cellular response to hypoxia

determination method

1 reference

9 May 2019

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

chromatin organization

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

regulation of DNA repair

determination method

1 reference

9 May 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

determination of adult lifespan

determination method

1 reference

9 May 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

regulation of bone mineralization

determination method

1 reference

9 May 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

regulation of multicellular organism growth

determination method

1 reference

9 May 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

positive regulation of histone H3-K9 trimethylation

determination method

1 reference

9 May 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

regulation of cellular senescence

determination method

1 reference

9 May 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

blastocyst hatching

determination method

1 reference

9 May 2019

Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

histone lysine methylation

determination method

3 references

9 May 2019

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54864

determination method

Post-SET domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54864

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54864

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54864

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54864

Chromo domain, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54864

Chromo/chromo shadow domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54864

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000111299

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000111299

ENSMUSP00000111301

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000111301

ENSMUSP00000111300

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000111300

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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