Protein tyrosine phosphatase, non-receptor type 6 (Q21983012)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Mus musculus

PTP-1C
SH-PTP1
SH2 phosphatase 1
SHP-1
protein-tyrosine phosphatase 1C
70Z-SHP
motheaten
hematopoietic cell protein-tyrosine phosphatase
Ptpn6
tyrosine-protein phosphatase non-receptor type 6
PTPTY-42

Language	Label	Description	Also known as
English	Protein tyrosine phosphatase, non-receptor type 6	mammalian protein found in Mus musculus	PTP-1C SH-PTP1 SH2 phosphatase 1 SHP-1 protein-tyrosine phosphatase 1C 70Z-SHP motheaten hematopoietic cell protein-tyrosine phosphatase Ptpn6 tyrosine-protein phosphatase non-receptor type 6 PTPTY-42

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Protein-tyrosine phosphatase, non-receptor type-6, -11

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29351

Protein-tyrosine phosphatase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29351

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29351

Tyrosine specific protein phosphatases domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTP type protein phosphatase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

SH3 domain binding

determination method

1 reference

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

phosphatase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

SH2 domain binding

determination method

1 reference

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

protein binding

determination method

21 references

8 April 2019

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Molecular cloning, biochemical and structural analysis of elongation factor-1 alpha from Leishmania donovani: comparison with the mammalian homologue.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

transmembrane receptor protein tyrosine phosphatase activity

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

cell adhesion molecule binding

determination method

1 reference

8 April 2019

Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

protein tyrosine phosphatase activity

determination method

10 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

The sialoadhesin CD33 is a myeloid-specific inhibitory receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

phosphotyrosine residue binding

determination method

natural killer cell lectin-like receptor binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

determination method

4 references

8 April 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

cell-cell junction

determination method

1 reference

8 April 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

alpha-beta T cell receptor complex

determination method

1 reference

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

biological process

B cell receptor signaling pathway

determination method

1 reference

14 February 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

megakaryocyte development

determination method

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

cell differentiation

determination method

intracellular signal transduction

determination method

1 reference

8 April 2019

Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

regulation of release of sequestered calcium ion into cytosol

determination method

1 reference

8 April 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

abortive mitotic cell cycle

determination method

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

protein dephosphorylation

determination method

6 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

8 April 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

platelet formation

determination method

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

negative regulation of T cell receptor signaling pathway

determination method

1 reference

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

negative regulation of humoral immune response mediated by circulating immunoglobulin

determination method

1 reference

8 April 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

negative regulation of T cell proliferation

determination method

1 reference

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

negative regulation of peptidyl-tyrosine phosphorylation

determination method

hematopoietic progenitor cell differentiation

determination method

1 reference

8 April 2019

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

regulation of ERK1 and ERK2 cascade

determination method

negative regulation of B cell receptor signaling pathway

determination method

1 reference

14 February 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

positive regulation of cell adhesion mediated by integrin

determination method

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

cell population proliferation

determination method

platelet aggregation

determination method

1 reference

8 April 2019

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

regulation of B cell differentiation

determination method

1 reference

8 April 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

natural killer cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Mutations in mice that influence natural killer (NK) cell activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

dephosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

negative regulation of interleukin-6 production

determination method

1 reference

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

8 April 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29351

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29351

Protein-tyrosine phosphatase, catalytic

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29351

PTP type protein phosphatase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29351

Tyrosine specific protein phosphatases domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29351

Protein-tyrosine phosphatase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29351

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000129124

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000129124

ENSMUSP00000134274

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000134274

ENSMUSP00000108103

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000108103

ENSMUSP00000134638

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000134638

ENSMUSP00000004377

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000004377

ENSMUSP00000133991

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000133991

ENSMUSP00000133429

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000133429

ENSMUSP00000133747

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000133747

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21983012&oldid=2023222517"