Ferrochelatase, mitochondrial (Q21983327)

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mouse protein (annotated by UniProtKB/Swiss-Prot P22315)
  • Heme synthase
  • Protoheme ferro-lyase
edit
Language Label Description Also known as
English
Ferrochelatase, mitochondrial
mouse protein (annotated by UniProtKB/Swiss-Prot P22315)
  • Heme synthase
  • Protoheme ferro-lyase

Statements

instance of
protein
0 references
molecular function
ferrochelatase activity
determination method
IDA
IEA
IMP
ISO
11 references
retrieved
16 September 2017
stated in
Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] cluster
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
ISO
retrieved
16 September 2017
stated in
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
16 September 2017
stated in
Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
16 September 2017
stated in
Ferrochelatase structural mutant (Fechm1Pas) in the house mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
16 September 2017
stated in
Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
16 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P22315
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IEA
retrieved
16 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IEA
retrieved
16 September 2017
stated in
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
16 September 2017
stated in
Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
16 September 2017
stated in
Probing the active site loop motif of murine ferrochelatase by random mutagenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
16 September 2017
stated in
The conserved active-site loop residues of ferrochelatase induce porphyrin conformational changes necessary for catalysis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IDA
ferrochelatase activity
determination method
IBA
IDA
IEA
IMP
ISO
12 references
retrieved
14 February 2019
stated in
Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] cluster
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
ISO
retrieved
14 February 2019
stated in
Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
14 February 2019
stated in
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
14 February 2019
stated in
Ferrochelatase structural mutant (Fechm1Pas) in the house mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
14 February 2019
stated in
Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22315
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IEA
retrieved
14 February 2019
stated in
Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
14 February 2019
stated in
Probing the active site loop motif of murine ferrochelatase by random mutagenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
14 February 2019
stated in
The conserved active-site loop residues of ferrochelatase induce porphyrin conformational changes necessary for catalysis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
14 February 2019
stated in
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IBA
cell component
biological process
heme biosynthetic process
determination method
IDA
IEA
TAS
IMP
8 references
retrieved
16 September 2017
stated in
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
TAS
retrieved
16 September 2017
stated in
Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
16 September 2017
stated in
Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
16 September 2017
stated in
Function of the [2FE-2S] cluster in mammalian ferrochelatase: a possible role as a nitric oxide sensor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
16 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P22315
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IEA
retrieved
16 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IEA
retrieved
16 September 2017
stated in
Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
16 September 2017
stated in
The conserved active-site loop residues of ferrochelatase induce porphyrin conformational changes necessary for catalysis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22315&geneProductId=UniProtKB:P22315
determination method
IDA
heme biosynthetic process
determination method
IBA
IDA
IEA
IMP
ISO
TAS
10 references
retrieved
14 February 2019
stated in
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
TAS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
ISO
retrieved
14 February 2019
stated in
Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
14 February 2019
stated in
Function of the [2FE-2S] cluster in mammalian ferrochelatase: a possible role as a nitric oxide sensor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
14 February 2019
stated in
Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22315
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IEA
retrieved
14 February 2019
stated in
Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
14 February 2019
stated in
The conserved active-site loop residues of ferrochelatase induce porphyrin conformational changes necessary for catalysis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22315
determination method
IBA

Identifiers

 
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