Forkhead box F1 (Q21983985)

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mammalian protein found in Mus musculus

Foxf1
hepatocyte nuclear factor 3 forkhead homolog 8
forkhead-related protein FKHL5
HFH-8
HNF-3/forkhead homolog 8
forkhead box protein F1
FREAC-1
forkhead-related transcription factor 1
forkhead box F1a

Language	Label	Description	Also known as
English	Forkhead box F1	mammalian protein found in Mus musculus	Foxf1 hepatocyte nuclear factor 3 forkhead homolog 8 forkhead-related protein FKHL5 HFH-8 HNF-3/forkhead homolog 8 forkhead box protein F1 FREAC-1 forkhead-related transcription factor 1 forkhead box F1a

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61080

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61080

Fork head domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fork head domain conserved site1, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fork head domain conserved site 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

sequence-specific DNA binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

DNA-binding transcription factor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61080&geneProductId=UniProtKB:Q61080

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61080&geneProductId=UniProtKB:Q61080

determination method

biological process

determination method

1 reference

9 May 2019

The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

lung morphogenesis

determination method

1 reference

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

embryonic foregut morphogenesis

determination method

1 reference

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

lung development

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

positive regulation of cell migration

determination method

1 reference

9 May 2019

Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

cellular response to organic cyclic compound

determination method

1 reference

9 May 2019

Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

extracellular matrix organization

determination method

1 reference

9 May 2019

Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

in utero embryonic development

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

negative regulation of transcription by RNA polymerase II

determination method

negative regulation of mast cell degranulation

determination method

1 reference

9 May 2019

Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

smooth muscle cell differentiation

determination method

1 reference

14 February 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61080&geneProductId=UniProtKB:Q61080

determination method

right lung morphogenesis

determination method

1 reference

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

cellular response to cytokine stimulus

determination method

1 reference

9 May 2019

The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

determination method

3 references

9 May 2019

The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

determination of left/right symmetry

determination method

1 reference

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

establishment of epithelial cell apical/basal polarity

determination method

1 reference

9 May 2019

Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

positive regulation of mesenchymal cell proliferation

determination method

1 reference

9 May 2019

The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

animal organ morphogenesis

determination method

1 reference

9 May 2019

Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

detection of wounding

determination method

1 reference

9 May 2019

Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

smoothened signaling pathway

determination method

1 reference

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

lateral mesodermal cell differentiation

determination method

1 reference

9 May 2019

The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

mesenchyme migration

determination method

1 reference

9 May 2019

Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

lung alveolus development

determination method

1 reference

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

mesoderm development

determination method

epithelial tube branching involved in lung morphogenesis

determination method

1 reference

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

negative regulation of inflammatory response

determination method

1 reference

9 May 2019

Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

embryonic digestive tract development

determination method

1 reference

9 May 2019

Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

lung lobe morphogenesis

determination method

1 reference

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

positive regulation of transcription by RNA polymerase II

determination method

6 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

epithelial cell differentiation involved in mammary gland alveolus development

determination method

1 reference

9 May 2019

Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

positive regulation of cell-substrate adhesion

determination method

1 reference

9 May 2019

Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61080&geneProductId=UniProtKB:Q61080

determination method

cell-cell adhesion

determination method

1 reference

9 May 2019

The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

trachea development

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

smooth muscle cell differentiation

determination method

3 references

9 May 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

9 May 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61080

determination method

Fork head domain conserved site 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61080

Fork head domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61080

Fork head domain conserved site1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61080

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000137662

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000137662

Sitelinks

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