Hes family bHLH transcription factor 3 (Q21984081)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61657

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Orange domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transcription factor binding

NAS

1 reference

9 May 2019

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

protein dimerization activity

NAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

1 reference

9 May 2019

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

DNA-binding transcription repressor activity, RNA polymerase II-specific

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

4 references

24 April 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61657&geneProductId=UniProtKB:Q61657

24 April 2018

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61657&geneProductId=UniProtKB:Q61657

14 February 2019

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

14 February 2019

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

DNA-binding transcription repressor activity, RNA polymerase II-specific

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

6 references

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61657&geneProductId=UniProtKB:Q61657

10 September 2018

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61657&geneProductId=UniProtKB:Q61657

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61657&geneProductId=UniProtKB:Q61657

9 May 2019

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

9 May 2019

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

transcription corepressor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

transcription factor binding

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

NAS

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

sequence-specific DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

sequence-specific double-stranded DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61657&geneProductId=UniProtKB:Q61657

1 reference

24 April 2018

biological process

hindbrain morphogenesis

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

trochlear nerve development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

midbrain-hindbrain boundary morphogenesis

1 reference

9 May 2019

Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

in utero embryonic development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

1 reference

9 May 2019

regulation of neurogenesis

1 reference

24 April 2018

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61657&geneProductId=UniProtKB:Q61657

regulation of timing of neuron differentiation

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

oculomotor nerve development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61657&geneProductId=UniProtKB:Q61657

1 reference

24 April 2018

neural tube development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

midbrain development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

positive regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

14 February 2019

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

somitogenesis

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

Notch signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

cell differentiation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

regulation of neurogenesis

negative regulation of transcription by RNA polymerase II

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

9 May 2019

Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

anterior/posterior pattern specification

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61657

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61657

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0