Histone deacetylase 3 (Q21984932)

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mammalian protein found in Mus musculus

protein deacylase HDAC3
Hdac3
HDAC3 splicing HDAC3beta
HDAC3 splicing HDAC3alpha
protein deacetylase HDAC3
HDAC3 splicing HDAC3delta
HD3
HDAC3 splicing HDAC3gamma
histone deacetylase 3

Language	Label	Description	Also known as
English	Histone deacetylase 3	mammalian protein found in Mus musculus	protein deacylase HDAC3 Hdac3 HDAC3 splicing HDAC3beta HDAC3 splicing HDAC3alpha protein deacetylase HDAC3 HDAC3 splicing HDAC3delta HD3 HDAC3 splicing HDAC3gamma histone deacetylase 3

Statements

1 reference

2 March 2022

UniProt protein ID

Histone deacetylase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88895

Ureohydrolase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88895

Histone deacetylase, subgroup

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88895

histone deacetylases

1 reference

based on heuristic

inferred from protein domain or family

1 reference

2 March 2022

UniProt protein ID

1 reference

2 March 2022

UniProt protein ID

molecular function

NAD-dependent histone deacetylase activity (H3-K14 specific)

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

histone deacetylase activity

determination method

4 references

24 April 2018

Class II histone deacetylases: versatile regulators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

protein deacetylase activity

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

transcription factor binding

determination method

3 references

8 April 2019

Class II histone deacetylases: versatile regulators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

histone deacetylase binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

chromatin binding

determination method

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

NF-kappaB binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

protein binding

determination method

12 references

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Adipose is a conserved dosage-sensitive antiobesity gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Chromatin regulation by Brg1 underlies heart muscle development and disease

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

chromatin DNA binding

determination method

1 reference

8 April 2019

Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

deacetylase activity

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

histone deacetylase activity

determination method

5 references

8 April 2019

Class II histone deacetylases: versatile regulators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

determination method

7 references

8 April 2019

Class II histone deacetylases: versatile regulators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

histone deacetylase complex

determination method

1 reference

24 April 2018

Class II histone deacetylases: versatile regulators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

plasma membrane

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

spindle microtubule

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

determination method

7 references

8 April 2019

Class II histone deacetylases: versatile regulators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

histone deacetylase complex

determination method

3 references

8 April 2019

Class II histone deacetylases: versatile regulators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

mitotic spindle

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

biological process

histone H3 deacetylation

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

regulation of transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

regulation of multicellular organism growth

determination method

1 reference

8 April 2019

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

negative regulation of transcription by RNA polymerase II

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

circadian regulation of gene expression

determination method

1 reference

14 January 2019

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

spindle assembly

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

protein deacetylation

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

negative regulation of JNK cascade

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

negative regulation of cardiac muscle cell differentiation

determination method

1 reference

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

histone deacetylation

determination method

3 references

8 April 2019

The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

JDP2 suppresses adipocyte differentiation by regulating histone acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

histone H4 deacetylation

determination method

1 reference

24 April 2018

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

determination method

histone H4-K12 deacetylation

determination method

1 reference

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

negative regulation of interleukin-1 production

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

positive regulation of neuron apoptotic process

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

negative regulation of protein export from nucleus

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

positive regulation of type B pancreatic cell apoptotic process

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

histone H3 deacetylation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

positive regulation of cold-induced thermogenesis

determination method

1 reference

8 April 2019

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

positive regulation of protein ubiquitination

determination method

1 reference

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

regulation of circadian rhythm

determination method

1 reference

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

rhythmic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

determination method

Histone deacetylase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88895

Identifiers

RefSeq protein ID

1 reference

4 March 2022

UniProt protein ID

1 reference

2 March 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000158234

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000158234

ENSMUSP00000037981

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000037981

ENSMUSP00000157755

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000157755

Sitelinks

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