Nucleolar protein 3 (apoptosis repressor with CARD domain) (Q21985168)

http://www.ebi.ac.uk/interpro/protein/Q9D1X0

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

CARD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

death receptor binding

1 reference

14 February 2019

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

signaling receptor binding

1 reference

14 February 2019

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

14 February 2019

Characterization of ARC, apoptosis repressor interacting with CARD, in normal and dystrophin-deficient skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

2 references

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

14 February 2019

Characterization of ARC, apoptosis repressor interacting with CARD, in normal and dystrophin-deficient skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

regulation of apoptotic process

IDA

sarcoplasmic reticulum

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of striated muscle cell apoptotic process

IEA

1 reference

14 February 2019

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of tumor necrosis factor-mediated signaling pathway

1 reference

14 February 2019

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of muscle atrophy

1 reference

14 February 2019

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

response to injury involved in regulation of muscle adaptation

1 reference

14 February 2019

Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of apoptotic process

IEA

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

14 February 2019

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

cardiac muscle cell apoptotic process

IEA

1 reference

14 February 2019

Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

intrinsic apoptotic signaling pathway

1 reference

14 February 2019

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of cardiac muscle cell apoptotic process

1 reference

14 February 2019

Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension

blood vessel remodeling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

14 February 2019

Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

regulation of gene expression

1 reference

14 February 2019

Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of mitochondrial membrane permeability involved in apoptotic process

1 reference

14 February 2019

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of necrotic cell death

1 reference

14 February 2019

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

14 February 2019

Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

mRNA splice site selection

3 references

protein complex oligomerization

3 references

negative regulation of release of cytochrome c from mitochondria

3 references

regulation of NIK/NF-kappaB signaling

1 reference

14 February 2019

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

myoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

smooth muscle cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of mitochondrial calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

cellular response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

inhibition of cysteine-type endopeptidase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of death-inducing signaling complex assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of hydrogen peroxide-induced cell death

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of protein targeting to mitochondrion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

negative regulation of intrinsic apoptotic signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9D1X0

1 reference

InterPro Release 71.0