Mitogen-activated protein kinase kinase kinase 1 (Q21985560)

Armadillo-like helical

1 reference

Protein kinase-like domain superfamily

1 reference

Armadillo-type fold

1 reference

Zinc finger, RING-type, protein family

1 reference

Protein kinase domain, protein family

1 reference

Zinc finger, SWIM-type, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

10 August 2016

language of work or name

1 reference

10 August 2016

language of work or name

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

cytoskeletal protein binding

IEA

1 reference

14 February 2019

Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

6 references

14 February 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

14 February 2019

PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

14 February 2019

Subdomain VIII is a specificity-determining region in MEKK1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

14 February 2019

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

14 February 2019

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

14 February 2019

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

2 references

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis

protein kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

14 February 2019

Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

14 February 2019

Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

MAP kinase kinase kinase activity

EXP

IEA

ubiquitin-protein transferase activity

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

mitogen-activated protein kinase kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

mitogen-activated protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

protein serine/threonine kinase activity

3 references

1 reference

14 February 2019

Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

regulation of cell migration

biological process

1 reference

14 February 2019

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

epithelial cell morphogenesis

1 reference

14 February 2019

Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

protein phosphorylation

1 reference

14 February 2019

1 reference

14 February 2019

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

apoptotic mitochondrial changes

IDA

1 reference

14 February 2019

MEKK1-induced apoptosis is mediated by Smac/Diablo release from the mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

camera-type eye development

1 reference

14 February 2019

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

transforming growth factor beta receptor signaling pathway

1 reference

14 February 2019

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

morphogenesis of an epithelial sheet

1 reference

14 February 2019

Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

regulation of mitotic cell cycle

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53349&geneProductId=UniProtKB:P53349

regulation of apoptotic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53349&geneProductId=UniProtKB:P53349

protein ubiquitination

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

stress-activated protein kinase signaling cascade

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

activation of protein kinase activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53349

has part(s)

Zinc finger, RING-type

1 reference

protein kinase, ATP binding site

1 reference

serine/threonine-protein kinase, active site

1 reference

protein kinase domain

1 reference

Zinc finger, SWIM-type

1 reference