Myocardin (Q21985830)

Myocardin

1 reference

SAP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

RPEL repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transcription coactivator activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

1 reference

24 April 2018

IBA

R-SMAD binding

1 reference

14 February 2019

Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

histone deacetylase binding

1 reference

14 February 2019

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

protein binding

7 references

14 February 2019

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

histone acetyltransferase binding

1 reference

14 February 2019

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

RNA polymerase II-specific DNA-binding transcription factor binding

1 reference

14 February 2019

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

core promoter sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

cell component

nuclear speck

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

1 reference

14 February 2019

SRF-myogenin-E12 complex

IC

1 reference

14 February 2019

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

IC

nucleus

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Muscle-specific signaling mechanism that links actin dynamics to serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Myocardin is required for cardiomyocyte survival and maintenance of heart function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

cellular component maintenance

biological process

1 reference

14 February 2019

Myocardin is required for cardiomyocyte survival and maintenance of heart function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

positive regulation of transforming growth factor beta receptor signaling pathway

1 reference

14 February 2019

Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

1 reference

21 June 2018

urinary bladder development

1 reference

14 February 2019

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

vascular associated smooth muscle cell differentiation

1 reference

14 February 2019

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

cardiac muscle cell differentiation

1 reference

21 June 2018

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

cardiac ventricle development

1 reference

14 February 2019

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

regulation of cell growth by extracellular stimulus

1 reference

14 February 2019

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

positive regulation of DNA-binding transcription factor activity

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

21 June 2018

Expression and functional activity of four myocardin isoforms

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

negative regulation of transcription by RNA polymerase II

smooth muscle cell differentiation

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

21 June 2018

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

21 June 2018

Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

1 reference

21 June 2018

regulation of phenotypic switching

1 reference

14 February 2019

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

vasculogenesis

1 reference

14 February 2019

The serum response factor coactivator myocardin is required for vascular smooth muscle development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

positive regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Muscle-specific signaling mechanism that links actin dynamics to serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

uterus development

1 reference

14 February 2019

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

negative regulation of cardiac muscle cell apoptotic process

1 reference

14 February 2019

Myocardin is required for cardiomyocyte survival and maintenance of heart function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

heart development

1 reference

14 February 2019

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

regulation of myoblast differentiation

1 reference

14 February 2019

Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

regulation of histone acetylation

positive regulation of cell population proliferation

1 reference

14 February 2019

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

negative regulation of myotube differentiation

1 reference

14 February 2019

Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

positive regulation of cardiac muscle cell differentiation

ventricular cardiac muscle cell differentiation

1 reference

14 February 2019

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

positive regulation of DNA binding

1 reference

14 February 2019

The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

lung alveolus development

1 reference

14 February 2019

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

digestive tract development

1 reference

14 February 2019

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

ductus arteriosus closure

1 reference

14 February 2019

Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

positive regulation of transcription by RNA polymerase II

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Muscle-specific signaling mechanism that links actin dynamics to serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

transcription by RNA polymerase II

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VIM5&geneProductId=UniProtKB:Q8VIM5

positive regulation of gene expression

negative regulation of vascular associated smooth muscle cell proliferation

1 reference

14 February 2019

Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-β

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

negative regulation of vascular associated smooth muscle cell migration

1 reference

14 February 2019

Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-β

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

1 reference

14 February 2019

Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-β

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

positive regulation of epithelial to mesenchymal transition

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

hepatic stellate cell activation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

regulation of smooth muscle cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

cell growth involved in cardiac muscle cell development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

positive regulation of cardiac vascular smooth muscle cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

smooth muscle cell differentiation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM5

cardiac muscle cell differentiation

IBA

1 reference

SAP domain

1 reference