POU domain, class 4, transcription factor 1 (Q21986670)

Homeobox-like domain superfamily

1 reference

POU domain, class 4, transcription factor 1

1 reference

Homeobox domain, protein family

1 reference

POU domain, protein family

1 reference

POU-specific domain, protein family

1 reference

Cro/C1-type helix-turn-helix domain, protein family

1 reference

Homeobox, conserved site, protein family

1 reference

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

25 May 2022

1 reference

25 May 2022

3 references

14 February 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a target gene recognition in embryonic sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

24 April 2018

Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208

DNA-binding transcription activator activity, RNA polymerase II-specific

5 references

24 April 2018

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208

24 April 2018

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

4 references

14 February 2019

Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

IPI

1 reference

14 February 2019

Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

1 reference

14 February 2019

Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

single-stranded DNA binding

IPI

1 reference

14 February 2019

The different activities of the two activation domains of the Brn-3a transcription factor are dependent on the context of the binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

sequence-specific DNA binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

The different activities of the two activation domains of the Brn-3a transcription factor are dependent on the context of the binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

transcription coactivator activity

1 reference

14 February 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

transcription corepressor activity

1 reference

14 February 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a target gene recognition in embryonic sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

1 reference

14 February 2019

Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Barhl1 is required for maintenance of a large population of neurons in the zonal layer of the superior colliculus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

peripheral nervous system neuron development

biological process

4 references

14 February 2019

POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

regulation of transcription, DNA-templated

3 references

14 February 2019

Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

1 reference

14 February 2019

Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

trigeminal nerve development

1 reference

14 February 2019

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

neuron fate specification

ventricular compact myocardium morphogenesis

2 references

1 reference

14 February 2019

Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

cell migration in hindbrain

1 reference

14 February 2019

Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

negative regulation of apoptotic process

1 reference

14 February 2019

Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

negative regulation of transcription by RNA polymerase II

3 references

14 February 2019

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208

nervous system development

IEA

1 reference

14 February 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

negative regulation of transcription elongation by RNA polymerase I

IEA

1 reference

14 February 2019

Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

central nervous system neuron differentiation

Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleus

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

positive regulation of apoptotic process

1 reference

14 February 2019

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

peripheral nervous system neuron differentiation

1 reference

14 February 2019

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

1 reference

14 February 2019

Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

proprioception involved in equilibrioception

regulation of neurogenesis

1 reference

14 February 2019

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

sensory system development

1 reference

14 February 2019

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208

positive regulation of gene expression

IEA

1 reference

14 February 2019

The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

neuron projection development

1 reference

14 February 2019

The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

positive regulation of transcription by RNA polymerase II

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

negative regulation of programmed cell death

1 reference

14 February 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

positive regulation of osteoclast differentiation

1 reference

14 February 2019

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

cellular response to cytokine stimulus

1 reference

14 February 2019

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

cellular response to estradiol stimulus

1 reference

14 February 2019

POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

intrinsic apoptotic signaling pathway by p53 class mediator

1 reference

14 February 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

positive regulation of transcription regulatory region DNA binding

1 reference

14 February 2019

POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

negative regulation of neuron apoptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

14 February 2019

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

1 reference

14 February 2019

Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

negative regulation of gene expression

1 reference

14 February 2019

Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208

1 reference

Homeobox, conserved site

1 reference

POU-specific domain

1 reference

POU domain

1 reference

Cro/C1-type helix-turn-helix domain

1 reference