POU domain, class 3, transcription factor 2 (Q21986673)

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mammalian protein found in Mus musculus

octamer-binding transcription factor 7
brain-specific homeobox/POU domain protein 2
brain-2 class III POU-domain protein
Oct-7
Pou3f2
Brain-2
OTF-7
Brn-2
octamer-binding protein 7
nervous system-specific octamer-binding transcription factor N-Oct-3

Language	Label	Description	Also known as
English	POU domain, class 3, transcription factor 2	mammalian protein found in Mus musculus	octamer-binding transcription factor 7 brain-specific homeobox/POU domain protein 2 brain-2 class III POU-domain protein Oct-7 Pou3f2 Brain-2 OTF-7 Brn-2 octamer-binding protein 7 nervous system-specific octamer-binding transcription factor N-Oct-3

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Lambda repressor-like, DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31360

POU-domain transcription factor, class 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31360

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31360

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

POU domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

POU-specific domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

14 February 2019

Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

protein binding

determination method

1 reference

14 February 2019

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

transcription coactivator activity

determination method

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31360&geneProductId=UniProtKB:P31360

determination method

24 April 2018

Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31360&geneProductId=UniProtKB:P31360

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

DNA-binding transcription factor activity

determination method

sequence-specific DNA binding

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

HMG box domain binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

transcription coactivator activity

determination method

1 reference

5 June 2018

Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31360&geneProductId=UniProtKB:P31360

determination method

transcription regulator complex

determination method

1 reference

14 February 2019

The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

biological process

cellular response to organic substance

determination method

1 reference

14 February 2019

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

astrocyte development

determination method

1 reference

14 February 2019

Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

hypothalamus cell differentiation

determination method

1 reference

14 February 2019

Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

Schwann cell development

determination method

1 reference

14 February 2019

The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

negative regulation of gene expression

determination method

1 reference

14 February 2019

BRN2 is a transcriptional repressor of CDH13 (T-cadherin) in melanoma cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31360&geneProductId=UniProtKB:P31360

determination method

myelination in peripheral nervous system

determination method

1 reference

14 February 2019

The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

regulation of axonogenesis

determination method

1 reference

14 February 2019

Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

forebrain ventricular zone progenitor cell division

determination method

1 reference

14 February 2019

Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

neurohypophysis development

determination method

1 reference

14 February 2019

Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

positive regulation of multicellular organism growth

determination method

1 reference

14 February 2019

Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

epidermis development

determination method

1 reference

14 February 2019

Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

regulation of cell differentiation

determination method

1 reference

14 February 2019

Preferential differentiation of P19 mouse embryonal carcinoma cells into smooth muscle cells. Use of retinoic acid and antisense against the central nervous system-specific POU transcription factor Brn-2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

cerebral cortex radially oriented cell migration

determination method

1 reference

14 February 2019

Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

positive regulation of transcription by RNA polymerase II

determination method

transcription by RNA polymerase II

determination method

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31360&geneProductId=UniProtKB:P31360

determination method

regulation of transcription by RNA polymerase II

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

14 February 2019

Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

brain development

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

neuron fate commitment

determination method

1 reference

14 February 2019

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

neuron fate specification

determination method

1 reference

14 February 2019

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

neuron development

determination method

1 reference

14 February 2019

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

cell differentiation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31360

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000136147

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000136147

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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