POU domain, class 4, transcription factor 2 (Q21986679)

Homeobox-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Homeobox domain, protein family

1 reference

POU domain, protein family

1 reference

POU-specific domain, protein family

1 reference

Cro/C1-type helix-turn-helix domain, protein family

1 reference

Homeobox, conserved site, protein family

1 reference

DNA-binding transcription factor activity

1 reference

25 May 2022

1 reference

25 May 2022

2 references

3 references

14 February 2019

A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Isolation of three novel POU-domain containing cDNA clones from lactating mouse mammary gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

DNA-binding transcription activator activity, RNA polymerase II-specific

8 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

5 June 2018

Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

DNA-binding transcription repressor activity, RNA polymerase II-specific

2 references

5 June 2018

The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

14 February 2019

The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

sequence-specific DNA binding

6 references

5 June 2018

Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

5 June 2018

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

5 June 2018

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

5 June 2018

The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

5 June 2018

Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

transcription coactivator activity

1 reference

5 June 2018

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

transcription corepressor activity

1 reference

14 February 2019

Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

promoter-specific chromatin binding

1 reference

14 February 2019

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

1 reference

14 February 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

sequence-specific DNA binding

IPI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

intracellular anatomical structure

cell component

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

regulation of transcription, DNA-templated

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

1 reference

14 February 2019

POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

neuromuscular process controlling balance

1 reference

14 February 2019

Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

1 reference

14 February 2019

Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

transcription, DNA-templated

IGI

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

3 references

1 reference

14 February 2019

A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

positive regulation of cell differentiation

3 references

14 February 2019

Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development

neuron differentiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

1 reference

14 February 2019

Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

intracellular estrogen receptor signaling pathway

IGI

3 references

transcription by RNA polymerase II

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

negative regulation of DNA-binding transcription factor activity

1 reference

5 June 2018

Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

positive regulation of transcription by RNA polymerase II

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

positive regulation of programmed cell death

1 reference

5 June 2018

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

negative regulation of cell differentiation

1 reference

14 February 2019

Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

positive regulation of osteoclast differentiation

1 reference

14 February 2019

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

positive regulation of axon extension

1 reference

14 February 2019

POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

regulation of DNA-binding transcription factor activity

1 reference

5 June 2018

POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

cellular response to cytokine stimulus

1 reference

14 February 2019

Brn3 transcription factors control terminal osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

cellular response to estradiol stimulus

1 reference

5 June 2018

POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

intrinsic apoptotic signaling pathway by p53 class mediator

1 reference

5 June 2018

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

regulation of retinal ganglion cell axon guidance

1 reference

14 February 2019

A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

negative regulation of amacrine cell differentiation

1 reference

14 February 2019

Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

dorsal root ganglion development

1 reference

14 February 2019

POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

positive regulation of transcription regulatory region DNA binding

1 reference

5 June 2018

POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

negative regulation of transcription by RNA polymerase II

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

14 February 2019

The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

positive regulation of nucleic acid-templated transcription

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934

1 reference

14 February 2019

Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

cellular response to insulin stimulus

IGI

1 reference

14 February 2019

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

positive regulation of glucose import

1 reference

14 February 2019

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

negative regulation of adipose tissue development

1 reference

14 February 2019

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934

1 reference

Homeobox, conserved site

1 reference

POU-specific domain

1 reference

POU domain

1 reference

Cro/C1-type helix-turn-helix domain

1 reference