Aldhehyde dehydrogenase family 5, subfamily A1 (Q21986887)

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mammalian protein found in Mus musculus

succinate-semialdehyde dehydrogenase, mitochondrial
NAD(+)-dependent succinic semialdehyde dehydrogenase
aldehyde dehydrogenase 1, mitochondrial
Aldh5a1
aldehyde dehydrogenase family 5, subfamily A1
aldehyde dehydrogenase family 5 member A1

Language	Label	Description	Also known as
English	Aldhehyde dehydrogenase family 5, subfamily A1	mammalian protein found in Mus musculus	succinate-semialdehyde dehydrogenase, mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase aldehyde dehydrogenase 1, mitochondrial Aldh5a1 aldehyde dehydrogenase family 5, subfamily A1 aldehyde dehydrogenase family 5 member A1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Aldehyde/histidinol dehydrogenase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BWF0

Succinate semialdehyde dehydrogenase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BWF0

Aldehyde dehydrogenase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BWF0

Aldehyde dehydrogenase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BWF0

Aldehyde dehydrogenase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldehyde dehydrogenase, glutamic acid active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldehyde dehydrogenase, cysteine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

oxidoreductase activity

determination method

2 references

succinate-semialdehyde dehydrogenase [NAD(P)+] activity

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

succinate-semialdehyde dehydrogenase (NAD+) activity

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

carboxylic acid binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

determination method

6 references

31 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

31 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

31 January 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

31 January 2018

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

31 January 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

biological process

gamma-aminobutyric acid catabolic process

determination method

7 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

galactosylceramide metabolic process

determination method

1 reference

14 February 2019

Lipid abnormalities in succinate semialdehyde dehydrogenase (Aldh5a1-/-) deficient mouse brain provide additional evidence for myelin alterations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

glutathione metabolic process

determination method

1 reference

14 February 2019

Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

gamma-aminobutyric acid metabolic process

determination method

3 references

14 February 2019

Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Increased guanidino species in murine and human succinate semialdehyde dehydrogenase (SSADH) deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

14 February 2019

Succinic semialdehyde dehydrogenase deficiency: GABAB receptor-mediated function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

post-embryonic development

determination method

1 reference

14 February 2019

Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

short-chain fatty acid metabolic process

determination method

1 reference

14 February 2019

Lipid abnormalities in succinate semialdehyde dehydrogenase (Aldh5a1-/-) deficient mouse brain provide additional evidence for myelin alterations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

neurotransmitter catabolic process

determination method

1 reference

14 February 2019

Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

glucosylceramide metabolic process

determination method

1 reference

14 February 2019

Lipid abnormalities in succinate semialdehyde dehydrogenase (Aldh5a1-/-) deficient mouse brain provide additional evidence for myelin alterations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

glutamine metabolic process

determination method

1 reference

14 February 2019

Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

glucose metabolic process

determination method

1 reference

14 February 2019

Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

glutamate metabolic process

determination method

1 reference

14 February 2019

Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

glycerophospholipid metabolic process

determination method

1 reference

14 February 2019

Lipid abnormalities in succinate semialdehyde dehydrogenase (Aldh5a1-/-) deficient mouse brain provide additional evidence for myelin alterations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

respiratory electron transport chain

determination method

1 reference

14 February 2019

Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

acetate metabolic process

determination method

1 reference

14 February 2019

Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BWF0

determination method

succinate metabolic process

determination method

1 reference

31 January 2018

Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

glutamate decarboxylation to succinate

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

central nervous system development

determination method

4 references

31 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

31 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BWF0&geneProductId=UniProtKB:Q8BWF0

determination method

central nervous system development

determination method

3 references

Aldehyde dehydrogenase, glutamic acid active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BWF0

Aldehyde dehydrogenase, cysteine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BWF0

Aldehyde dehydrogenase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BWF0

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000040591

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000040591

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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