NK2 homeobox 2 (Q21987285)

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mammalian protein found in Mus musculus

homeobox protein Nkx-2.2
glycoprotein GP330, renal
NK2 transcription factor related, locus 2
homeobox protein Nkx2-2
Nkx2-2
homeobox protein NK-2 homolog B
Drosophila NK2 transcription factor related, locus 2

Language	Label	Description	Also known as
English	NK2 homeobox 2	mammalian protein found in Mus musculus	homeobox protein Nkx-2.2 glycoprotein GP330, renal NK2 transcription factor related, locus 2 homeobox protein Nkx2-2 Nkx2-2 homeobox protein NK-2 homolog B Drosophila NK2 transcription factor related, locus 2

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42586

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox domain, metazoa, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

2 references

protein binding

determination method

chromatin binding

determination method

1 reference

8 April 2019

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

DNA-binding transcription factor activity

determination method

transcription factor binding

determination method

1 reference

8 April 2019

Gata6 is an important regulator of mouse pancreas development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

DNA-binding transcription factor activity

determination method

3 references

8 April 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Conserved transcriptional regulatory domains of the pdx-1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

sequence-specific DNA binding

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Conserved transcriptional regulatory domains of the pdx-1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

intracellular anatomical structure

determination method

1 reference

24 April 2018

Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

determination method

7 references

7 November 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

7 November 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

7 November 2018

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

7 November 2018

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

7 November 2018

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

7 November 2018

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

determination method

8 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

biological process

spinal cord oligodendrocyte cell fate specification

determination method

1 reference

8 April 2019

Ascl1 is required for oligodendrocyte development in the spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

nervous system development

determination method

1 reference

8 April 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

response to organic cyclic compound

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

optic nerve development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

cell development

determination method

1 reference

8 April 2019

Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

positive regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

MicroRNA-23a promotes myelination in the central nervous system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

oligodendrocyte development

determination method

1 reference

8 April 2019

Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

response to glucose

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

pancreatic PP cell fate commitment

determination method

1 reference

8 April 2019

Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

cell differentiation

determination method

1 reference

7 November 2018

Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

ventral spinal cord interneuron fate determination

determination method

1 reference

8 April 2019

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

astrocyte differentiation

determination method

1 reference

8 April 2019

Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

spinal cord motor neuron differentiation

determination method

1 reference

8 April 2019

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

regulation of cell differentiation

determination method

1 reference

14 February 2019

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

pancreatic A cell fate commitment

determination method

type B pancreatic cell fate commitment

determination method

positive regulation of cell differentiation

determination method

1 reference

8 April 2019

The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

smoothened signaling pathway

determination method

1 reference

8 April 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

positive regulation of oligodendrocyte differentiation

determination method

1 reference

8 April 2019

Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

digestive tract development

determination method

1 reference

8 April 2019

Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

response to progesterone

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42586&geneProductId=UniProtKB:P42586

determination method

cell differentiation

determination method

3 references

8 April 2019

Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

8 April 2019

Conserved transcriptional regulatory domains of the pdx-1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42586

determination method

Homeobox domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42586

Homeobox, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42586

Homeobox domain, metazoa

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42586

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000069666

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000069666

ENSMUSP00000105596

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105596

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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