Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Q21987767)

Immunoglobulin-like fold

1 reference

Nuclear factor of activated T cells (NFAT)

1 reference

Rel homology domain (RHD), DNA-binding domain superfamily

1 reference

Immunoglobulin E-set

1 reference

IPT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology domain (RHD), DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Requirement of transcription factor NFAT in developing atrial myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

24 April 2018

NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

10 September 2018

NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

2 references

14 February 2019

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

DNA-binding transcription factor activity, RNA polymerase II-specific

IPI

1 reference

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

DNA-binding transcription factor activity

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Requirement of transcription factor NFAT in developing atrial myocardium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

transcription factor binding

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

DNA-binding transcription factor activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Requirement of transcription factor NFAT in developing atrial myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

transcription factor binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

DNA-binding transcription repressor activity, RNA polymerase II-specific

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

transcription regulator complex

cell component

1 reference

24 April 2018

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

3 references

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

cellular response to lithium ion

IEA

1 reference

14 February 2019

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

negative regulation of chromatin binding

1 reference

14 February 2019

Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

cellular response to UV

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

negative regulation of Wnt signaling pathway

1 reference

14 February 2019

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

calcineurin-NFAT signaling cascade

1 reference

24 April 2018

Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

positive regulation of apoptotic signaling pathway

1 reference

14 February 2019

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

negative regulation of transcription by RNA polymerase II

2 references

14 February 2019

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

negative regulation of protein binding

1 reference

14 February 2019

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

smooth muscle cell differentiation

1 reference

14 February 2019

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

negative regulation of synapse maturation

IEA

1 reference

14 February 2019

Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

negative regulation of dendrite morphogenesis

1 reference

14 February 2019

Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

intrinsic apoptotic signaling pathway in response to DNA damage

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

branching involved in blood vessel morphogenesis

1 reference

14 February 2019

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

positive regulation of apoptotic process

1 reference

14 February 2019

Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

1 reference

14 February 2019

NFATc3 and NFATc4 Are Required for Cardiac Development and Mitochondrial Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

muscle cell development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

positive regulation of transcription by RNA polymerase II

7 references

24 April 2018

Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

24 April 2018

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K120&geneProductId=UniProtKB:Q8K120

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

positive regulation of transcription by RNA polymerase II

8 references

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

1 reference

14 February 2019

Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

brain-derived neurotrophic factor receptor signaling pathway

1 reference

14 February 2019

Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

negative regulation of neuron apoptotic process

1 reference

14 February 2019

Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.

long-term potentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K120

Rel homology dimerisation domain

IEA

has part(s)

1 reference

IPT domain

1 reference

Rel homology domain (RHD), DNA-binding domain

1 reference