Lipin 1 (Q21988235)

http://www.ebi.ac.uk/interpro/protein/Q91ZP3

Phosphatidate phosphatase LPIN1

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q91ZP3

membrane protein

1 reference

inferred from GOA cell component → membrane

LNS2/PITP domain, protein family

1 reference

Lipin, N-terminal domain, protein family

1 reference

Lipin, middle domain, protein family

1 reference

Lipin/Ned1/Smp2 (LNS2), protein family

1 reference

histone deacetylase binding

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

1 reference

14 February 2019

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

peroxisome proliferator activated receptor binding

IPI

1 reference

5 June 2018

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

phosphatidate phosphatase activity

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

transcription coactivator activity

IDA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

phosphatidate phosphatase activity

IBA

5 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

14 January 2019

Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

14 January 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

phosphatidate phosphatase activity

IBA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

endoplasmic reticulum membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

transcription regulator complex

1 reference

14 February 2019

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

IDA

endoplasmic reticulum

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 June 2018

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

positive regulation of histone deacetylation

biological process

1 reference

14 February 2019

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

actin cytoskeleton reorganization

1 reference

14 February 2019

Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

regulation of transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling

mitochondrial fission

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

1 reference

14 February 2019

Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

regulation of fat cell differentiation

IGI

1 reference

14 February 2019

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

fat cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

positive regulation of transcription by RNA polymerase II

NAS

triglyceride mobilization

IDA

IGI

1 reference

5 June 2018

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

positive regulation of nucleic acid-templated transcription

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91ZP3&geneProductId=UniProtKB:Q91ZP3

1 reference

14 February 2019

Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

cellular response to insulin stimulus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

cellular lipid metabolic process

IBA

1 reference

14 February 2019

Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3

positive regulation of cold-induced thermogenesis

1 reference

14 February 2019

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZP3