R-spondin 1 (Q21988509)

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mammalian protein found in Mus musculus

R-spondin homolog
cristin-3
roof plate-specific spondin-1
mCristin-3
R-spondin-1
thrombospondin type 1 domain containing gene Rspondin
Rspo1
cysteine-rich and single thrombospondin domain-containing protein 3

Language	Label	Description	Also known as
English	R-spondin 1	mammalian protein found in Mus musculus	R-spondin homolog cristin-3 roof plate-specific spondin-1 mCristin-3 R-spondin-1 thrombospondin type 1 domain containing gene Rspondin Rspo1 cysteine-rich and single thrombospondin domain-containing protein 3

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Thrombospondin type-1 (TSP1) repeat superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z132

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z132

Thrombospondin type-1 (TSP1) repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Furin-like repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

1 reference

14 February 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

G protein-coupled receptor binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

frizzled binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

extracellular region

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

extracellular space

determination method

2 references

27 March 2018

R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z132&geneProductId=UniProtKB:Q9Z132

determination method

27 March 2018

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z132&geneProductId=UniProtKB:Q9Z132

determination method

extracellular space

determination method

3 references

14 February 2019

R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

14 February 2019

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

biological process

male meiotic nuclear division

determination method

1 reference

14 February 2019

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

regulation of receptor internalization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

regulation of gene expression

determination method

1 reference

14 February 2019

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

canonical Wnt signaling pathway

determination method

1 reference

14 February 2019

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

positive regulation of protein phosphorylation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

positive regulation of non-canonical Wnt signaling pathway

determination method

1 reference

14 February 2019

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

Wnt signaling pathway

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

response to stimulus

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

regulation of male germ cell proliferation

determination method

1 reference

14 February 2019

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

positive regulation of canonical Wnt signaling pathway

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

14 February 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132

determination method

Furin-like repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z132

Thrombospondin type-1 (TSP1) repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z132

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000030687

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000030687

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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