Glutamate receptor, ionotropic, NMDA2C (epsilon 3) (Q21988799)

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mammalian protein found in Mus musculus

glutamate [NMDA] receptor subunit epsilon-3
NR2C
Grin2c
GluRepsilon3
N-methyl D-aspartate receptor subtype 2C
NMDAR2C
glutamate receptor ionotropic, NMDA 2C

Language	Label	Description	Also known as
English	Glutamate receptor, ionotropic, NMDA2C (epsilon 3)	mammalian protein found in Mus musculus	glutamate [NMDA] receptor subunit epsilon-3 NR2C Grin2c GluRepsilon3 N-methyl D-aspartate receptor subtype 2C NMDAR2C glutamate receptor ionotropic, NMDA 2C

Statements

1 reference

25 May 2022

UniProt protein ID

0 references

Periplasmic binding protein-like I

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01098

ionotropic glutamate receptor, metazoa

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01098

Receptor, ligand binding region, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ionotropic glutamate receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Glutamate [NMDA] receptor, epsilon subunit, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

ion channel activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

protein binding

determination method

5 references

14 February 2019

Differential expression and co-assembly of NMDA zeta 1 and epsilon subunits in the mouse cerebellum during postnatal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

extracellularly glutamate-gated ion channel activity

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

NMDA glutamate receptor activity

determination method

8 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Molecular diversity of the NMDA receptor channel

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

glutamate-gated calcium ion channel activity

determination method

3 references

signaling receptor activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

ionotropic glutamate receptor activity

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

cation channel activity

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

PDZ domain binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

protein N-terminus binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

NMDA glutamate receptor activity

determination method

9 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Molecular diversity of the NMDA receptor channel

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

determination method

2 references

integral component of membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

postsynaptic membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

determination method

2 references

plasma membrane

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

intracellular anatomical structure

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

NMDA selective glutamate receptor complex

determination method

3 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

NMDA selective glutamate receptor complex

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

postsynaptic density membrane

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

glutamatergic synapse

determination method

2 references

biological process

startle response

determination method

1 reference

14 February 2019

Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

neuromuscular process controlling balance

determination method

1 reference

14 February 2019

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

negative regulation of protein catabolic process

determination method

1 reference

14 February 2019

NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

regulation of membrane potential

determination method

1 reference

14 February 2019

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

directional locomotion

determination method

1 reference

14 February 2019

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

determination method

2 references

response to wounding

determination method

1 reference

14 February 2019

Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

excitatory postsynaptic potential

determination method

3 references

24 April 2018

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

24 April 2018

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01098&geneProductId=UniProtKB:Q01098

determination method

ionotropic glutamate receptor signaling pathway

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

calcium-mediated signaling

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

calcium ion transmembrane import into cytosol

determination method

3 references

protein localization to postsynaptic membrane

determination method

excitatory postsynaptic potential

determination method

4 references

14 February 2019

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

long-term potentiation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01098

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000003351

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000003351

ENSMUSP00000102164

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000102164

Sitelinks

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