Peroxiredoxin 2 (Q21989941)

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mammalian protein found in Mus musculus

protector protein
Prx II-1
thiol-specific antioxidant protein
thioredoxin-dependent peroxiredoxin 2
thioredoxin peroxidase 1
Calpromotin
TSA
Prdx2
peroxiredoxin-2
Trx dependent peroxide reductase 1
thioredoxin-dependent peroxide reductase 1
thioredoxin reductase

Language	Label	Description	Also known as
English	Peroxiredoxin 2	mammalian protein found in Mus musculus	protector protein Prx II-1 thiol-specific antioxidant protein thioredoxin-dependent peroxiredoxin 2 thioredoxin peroxidase 1 Calpromotin TSA Prdx2 peroxiredoxin-2 Trx dependent peroxide reductase 1 thioredoxin-dependent peroxide reductase 1 thioredoxin reductase

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Thioredoxin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61171

Peroxiredoxin, AhpC-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61171

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant, protein family

1 reference

based on heuristic

inferred from protein domain or family

Thioredoxin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peroxiredoxin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

selenium binding

determination method

1 reference

8 April 2019

Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

antioxidant activity

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

protein binding

determination method

1 reference

8 April 2019

Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

thioredoxin peroxidase activity

determination method

3 references

31 January 2018

The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

31 January 2018

Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

31 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

thioredoxin peroxidase activity

determination method

5 references

8 April 2019

The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

determination method

1 reference

31 January 2018

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

determination method

1 reference

31 January 2018

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

determination method

1 reference

8 April 2019

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

determination method

determination method

1 reference

8 April 2019

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

biological process

regulation of apoptotic process

determination method

1 reference

31 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

homeostasis of number of cells

determination method

1 reference

8 April 2019

Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

regulation of hydrogen peroxide metabolic process

determination method

1 reference

8 April 2019

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

thymus development

determination method

1 reference

8 April 2019

Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

negative regulation of extrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

negative regulation of lipopolysaccharide-mediated signaling pathway

determination method

1 reference

8 April 2019

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

T cell proliferation

determination method

1 reference

8 April 2019

Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

respiratory burst involved in inflammatory response

determination method

1 reference

8 April 2019

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

hydrogen peroxide metabolic process

determination method

2 references

response to lipopolysaccharide

determination method

1 reference

8 April 2019

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

positive regulation of blood coagulation

determination method

1 reference

8 April 2019

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

hydrogen peroxide catabolic process

determination method

1 reference

31 January 2018

Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

cellular response to oxidative stress

determination method

1 reference

31 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

negative regulation of reactive oxygen species metabolic process

determination method

1 reference

14 February 2019

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

negative regulation of T cell differentiation

determination method

1 reference

8 April 2019

T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

cell redox homeostasis

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

response to oxidative stress

determination method

4 references

8 April 2019

Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

removal of superoxide radicals

determination method

3 references

1 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

1 January 2018

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61171&geneProductId=UniProtKB:Q61171

determination method

negative regulation of neuron apoptotic process

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

removal of superoxide radicals

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

leukocyte activation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61171

determination method

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61171

Peroxiredoxin, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61171

Thioredoxin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61171

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000005292

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000005292

ENSMUSP00000105355

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105355

ENSMUSP00000105356

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105356

ENSMUSP00000126451

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000126451

ENSMUSP00000122694

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000122694

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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