Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (Q21990391)

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mammalian protein found in Mus musculus
  • NRAMP 1
  • solute carrier family 11 member 1
  • natural resistance-associated macrophage protein 1
  • Slc11a1
  • host resistance locus Bcg/Ity/Lsh
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Language Label Description Also known as
English
Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
mammalian protein found in Mus musculus
  • NRAMP 1
  • solute carrier family 11 member 1
  • natural resistance-associated macrophage protein 1
  • Slc11a1
  • host resistance locus Bcg/Ity/Lsh

Statements

molecular function
cell component
phagocytic vesicle membrane
determination method
IDA
IEA
IMP
ISO
6 references
retrieved
10 September 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251
determination method
ISO
retrieved
10 September 2018
stated in
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251
determination method
IEA
retrieved
10 September 2018
stated in
Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251
determination method
IDA
retrieved
10 September 2018
stated in
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251
determination method
IDA
retrieved
10 September 2018
stated in
Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251
determination method
IDA
phagocytic vesicle membrane
determination method
IBA
IDA
IEA
IMP
ISO
7 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
ISO
retrieved
9 May 2019
stated in
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IEA
retrieved
9 May 2019
stated in
Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IDA
retrieved
9 May 2019
stated in
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IDA
retrieved
9 May 2019
stated in
Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IBA
biological process
defense response to bacterium
determination method
IMP
5 references
retrieved
9 May 2019
stated in
Genetic resistance of mice to Mycobacterium paratuberculosis is influenced by Slc11a1 at the early but not at the late stage of infection
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
Contribution of interferon gamma and membrane-associated interleukin 1 to the resistance to murine typhoid of Ityr mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
Locating salmonella resistance gene on mouse chromosome 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
cellular iron ion homeostasis
determination method
IBA
IEA
IMP
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
ISO
retrieved
9 May 2019
stated in
Nramp1 equips macrophages for efficient iron recycling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IBA
response to lipopolysaccharide
determination method
IBA
IDA
IMP
ISO
5 references
retrieved
9 May 2019
stated in
Cloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor alpha, and interleukin-1beta: role of CD14 and mitogen-activated protein kinases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
ISO
retrieved
9 May 2019
stated in
Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IMP
retrieved
9 May 2019
stated in
Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251
determination method
IBA

Identifiers

 
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