A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response (Q22001534)

modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

6

Chihiro Sasakawa

Chihiro

Sasakawa

1 reference

18 September 2022

Marc Schmidt-Supprian

3

object named as

Marc Schmidt-Supprian

Marc

Schmidt-Supprian

1 reference

18 September 2022

Hiroshi Ashida

1

Hiroshi

Ashida

1 reference

18 September 2022

Minsoo Kim

2

Minsoo

Kim

1 reference

18 September 2022

Averil Ma

4

Averil

Ma

1 reference

18 September 2022

Michinaga Ogawa

5

Michinaga

Ogawa

1 reference

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

18 September 2022

language of work or name

English

0 references

publication date

January 2010

0 references

published in

Nature Cell Biology

0 references

volume

12

0 references

page(s)

66-73; sup pp 1-9

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issue

1

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Structure of a Shigella effector reveals a new class of ubiquitin ligases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Pathogen recognition and innate immunity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

The versatility of Shigella effectors

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

NF-kappaB regulation in the immune system

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation

19 March 2017

1 reference

https://api.crossref.org/works/10.1038/NCB2006

The inflammasomes: guardians of the body

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Ubiquitin signalling in the NF-kappaB pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Manipulation of host-cell pathways by bacterial pathogens

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Debugging how bacteria manipulate the immune response.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Nod-like proteins in immunity, inflammation and disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Posttranslational modifications of NEMO and its partners in NF-kappaB signaling

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Ubiquitylation and cell signaling

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107189

Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses

30 May 2018

1 reference

Type III secretion effectors of the IpaH family are E3 ubiquitin ligases.

21 January 2018

1 reference

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

21 January 2018

1 reference

Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus

21 January 2018

1 reference

Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20010814

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCB2006

1 reference

4814631

0 references

4814631

1 reference

1 reference

1 reference