KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation (Q22009020)

positive regulation of MAP kinase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

B Bell

1

B

Bell

1 reference

7 February 2023

H Xing

2

H

Xing

1 reference

7 February 2023

K Yan

3

K

Yan

1 reference

7 February 2023

N Gautam

4

N

Gautam

1 reference

7 February 2023

A J Muslin

5

A J

Muslin

1 reference

Journal of Biological Chemistry

7 February 2023

language of work or name

English

0 references

publication date

19 March 1999

0 references

published in

0 references

volume

274

0 references

issue

12

0 references

page(s)

7982-6

0 references

cites work

Increasing complexity of the Ras signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

KSR, a novel protein kinase required for RAS signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

The protein kinase KSR interacts with 14-3-3 protein and Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

KSR modulates signal propagation within the MAPK cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

KSR stimulates Raf-1 activity in a kinase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Activation of Raf-1 by 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Design of oligonucleotide probes for molecular cloning of beta and gamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Characterization of antibodies for various G-protein beta and gamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Identification of two forms of the gamma subunit of G protein, gamma10 and gamma11, in bovine lung and their tissue distribution in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Lysophosphatidic acid: G-protein signalling and cellular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Molecular basis for interactions of G protein betagamma subunits with effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Structural determinants for interaction with three different effectors on the G protein beta subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

The 2.0 A crystal structure of a heterotrimeric G protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein gamma subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

7 January 2021

The G-protein betagamma complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

7 January 2021

A domain on the G protein beta subunit interacts with both adenylyl cyclase 2 and the muscarinic atrial potassium channel

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

7 January 2021

The coiled-coil region of the G protein beta subunit. Mutational analysis of Ggamma and effector interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

7 January 2021

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.12.7982

7 January 2021

Identifiers

DOI

10.1074/JBC.274.12.7982

0 references