The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis (Q22009525)

apoptotic signaling pathway

GOA release 2020-03-11

1 reference

Caspase 8 associated protein 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Y Imai

1

Yuzuru

Imai

1 reference

6 February 2023

T Kimura

2

Takaharu

Kimura

1 reference

6 February 2023

A Murakami

3

Akira

Murakami

1 reference

6 February 2023

N Yajima

4

Nobuyuki

Yajima

1 reference

6 February 2023

K Sakamaki

5

Kazuhiro

Sakamaki

1 reference

6 February 2023

S Yonehara

6

Shin

Yonehara

1 reference

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

6 February 2023

language of work or name

English

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publication date

29 April 1999

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published in

Nature

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volume

398

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issue

6730

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page(s)

777-85

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cites work

1 reference

Apoptosis by death factor

21 January 2018

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A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

21 January 2018

1 reference

Monoclonal antibody-mediated tumor regression by induction of apoptosis.

21 January 2018

1 reference

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

21 January 2018

1 reference

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

21 January 2018

1 reference

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

21 January 2018

1 reference

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

21 January 2018

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 January 2018

1 reference

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

21 January 2018

1 reference

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

An induced proximity model for caspase-8 activation.

21 January 2018

1 reference

Autoproteolytic activation of pro-caspases by oligomerization.

21 January 2018

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Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

21 January 2018

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Caspases and caspase inhibitors

21 January 2018

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 January 2018

1 reference

Role of CED-4 in the activation of CED-3.

21 January 2018

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE.

21 January 2018

1 reference

Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

1 reference

The scanning model for translation: an update

21 January 2018

1 reference

Nucleocytoplasmic transport: signals, mechanisms and regulation

21 January 2018

1 reference

Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

21 January 2018

1 reference

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

21 January 2018

1 reference

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

21 January 2018

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

21 January 2018

1 reference

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

21 January 2018

1 reference

DEDD, a novel death effector domain-containing protein, targeted to the nucleolus

21 January 2018

1 reference

Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex.

21 January 2018

1 reference

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

21 January 2018

1 reference

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

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Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

21 January 2018

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Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

21 January 2018

1 reference

Molecular cloning and characterization of mouse caspase-8

21 January 2018

1 reference

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

21 January 2018

1 reference

The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals

21 January 2018

1 reference

Apoptosis CED-4 is a stranger no more

21 January 2018

1 reference

Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8

21 January 2018

1 reference

7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

1 reference

7 January 2021

1 reference

7 January 2021

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation

1 reference

7 January 2021

Involvement of apoptosis antigen Fas in clonal deletion of human thymocytes

1 reference

7 January 2021