IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain (Q22010650)

GOA release 2020-03-11

phosphate ion binding

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

H Sakurai

1

H

Sakurai

1 reference

7 February 2023

H Chiba

2

H

Chiba

1 reference

7 February 2023

H Miyoshi

series ordinal

3

author given names

H

author last names

Miyoshi

1 reference

7 February 2023

T Sugita

series ordinal

4

author given names

T

author last names

Sugita

1 reference

7 February 2023

W Toriumi

series ordinal

5

author given names

W

author last names

Toriumi

1 reference

7 February 2023

language of work or name

English

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publication date

22 October 1999

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published in

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volume

274

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page(s)

30353-6

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issue

43

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cites work

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

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TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism

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Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

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I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B

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Identification and characterization of an IkappaB kinase

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

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NF-kappa B: ten years after

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HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.

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Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

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7 January 2021

Cloning and functional characterization of mouse IkappaBepsilon

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Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

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Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells

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Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo

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Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha

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Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

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7 January 2021

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.

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7 January 2021

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

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7 January 2021

Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity

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IKK1-deficient mice exhibit abnormal development of skin and skeleton

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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7 January 2021

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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7 January 2021

Limb and skin abnormalities in mice lacking IKKalpha

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7 January 2021

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

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https://api.crossref.org/works/10.1074%2FJBC.274.43.30353

7 January 2021

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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7 January 2021

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

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7 January 2021

A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription

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7 January 2021

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

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7 January 2021

Function and activation of NF-kappa B in the immune system

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7 January 2021